红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

郑颖琳; 佟奕辰; 孙英英; 庞冀燕

doi:10.13471/j.cnki.jsysusse.2020.01.016

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红树林真菌Aspergillus sp. 次级代谢产物及其生物活性

更新时间：2023-12-12

- 红树林真菌Aspergillus sp. 次级代谢产物及其生物活性
- Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities
- 中山大学学报(自然科学版)(中英文) 2020年59卷第1期页码：133-143
- 作者机构：
  
  1. ．中山大学化学学院,广东,广州,510275
  2. 广东省药物新剂型重点实验室/广东药科大学,广东,广州,510006
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.jsysusse.2020.01.016
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-1-25，
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郑颖琳, 佟奕辰, 孙英英, 等. 红树林真菌Aspergillus sp. 次级代谢产物及其生物活性[J]. 中山大学学报(自然科学版)(中英文), 2020,59(1):133-143.

ZHENG Yinglin, TONG Yichen, SUN Yingying, et al. Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2020,59(1):133-143.
郑颖琳, 佟奕辰, 孙英英, 等. 红树林真菌Aspergillus sp. 次级代谢产物及其生物活性[J]. 中山大学学报(自然科学版)(中英文), 2020,59(1):133-143. DOI： 10.13471/j.cnki.jsysusse.2020.01.016.

ZHENG Yinglin, TONG Yichen, SUN Yingying, et al. Secondary metabolites from mangrove fungus Aspergillus sp. and their biological activities[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2020,59(1):133-143. DOI： 10.13471/j.cnki.jsysusse.2020.01.016.

摘要

从曲霉属海洋真菌（〖

Aspergillus sp

.）中分离出17种化合物 (

1-17

)，其结构由核磁共振波谱（NMR）、质谱（MS）等谱学方法得以确证。其中，化合物

系首次于自然界中被发现，化合物

2-17

则为已知化合物。对其中部分化合物进行了初步的生物活性测试。其中，化合物

对RPMI8226

OCIMY5及MCF-7细胞表现出了中等的抑制活性，化合物

对热应激下的线虫表现出了显著的保护作用。此外，化合物

及

对化脓性链球菌（

Streptococcus pyogenes

）表现出轻度的抑制作用，而化合物

则对肺炎链球菌（

Streptococcus pneumoniae

）表现出轻度的抑制作用。

Abstract

Seventeen compounds (

1-17

) were isolated from the marine fungus

Aspergillus sp

. Their structures were determined by nuclear magnetic resonance (NMR) spectroscopy and mass spectrum (MS). Among them

compound 1 was first found as a naturally occurring compound and the known compounds

2-17

were confirmed via spectrum and literatures. The bioactivities of selected compounds were preliminarily evaluated. The compound 2 exhibited moderate inhibitory activities toward three cancer cells

RPMI8226

OCI-MY5

and MCF-7 cells

and compound

had significant protective effects on prolonging the survival life of

C. elegans

under heat stress. In addition

the compound

and

showed slight inhibition effects against

Streptococcus pyogenes

and meanwhile the compound

possessed slightly inhibitory activity on

Streptococcus pneumoniae

关键词

海洋真菌天然产物细胞毒活性神经保护活性抗菌活性

Keywords

marine fungusnatural productscytotoxicityneuroprotective effectsantibacterial effects

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