脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展

严曾豪; 张伟健; 吴灏; 陈滔彬; 何彦; 苏薇薇

doi:10.13471/j.cnki.acta.snus.2020.08.05.2020E033

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脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展

研究论文 | 更新时间：2023-12-08

- 脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展
- Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases
- 中山大学学报(自然科学版) 2021年60卷第3期页码：12-18
- 作者机构：
  
  广东省中药上市后质量与药效再评价工程技术研究中心/广东省热带亚热带植物资源重点实验室/中山大学生命科学学院，广东广州 510275
- 作者简介：
  
  严曾豪（1993年生）；研究方向：中药作用和机制；E-mail：yanzengh@yeah.net
  苏薇薇（1959年生）；研究方向：创新药物研制、中药上市后再评价及中药国际化；教授、博士生导师；广东省中药上市后质量与药效再评价工程技术研究中心主任；研究领域为创新药物研制、中药上市后再评价及中药国际化；发表论文400余篇（其中SCI收录135篇）；出版专著18部（第一著者）；获得中国发明专利授权82件，国际专利授权7件。现任世界中医药学会联合会网络药理学专业委员会副会长，广东省中医药学会网络药理学专业委员会主任委员。E-mail：lsssww@126.com
- 基金信息：
  
  广东省基础与应用基础研究基金(2019A1515010604)
- DOI：10.13471/j.cnki.acta.snus.2020.08.05.2020E033
  中图分类号： R285
- 纸质出版日期：2021-05-25，
  
  网络出版日期：2021-04-15，
  
  收稿日期：2020-08-05，
  
  录用日期：2020-10-28
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严曾豪,张伟健,吴灏等.脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展[J].中山大学学报(自然科学版),2021,60(03):12-18.

YAN Zenghao,ZHANG Weijian,WU Hao,et al.Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(03):12-18.
严曾豪,张伟健,吴灏等.脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展[J].中山大学学报(自然科学版),2021,60(03):12-18. DOI： 10.13471/j.cnki.acta.snus.2020.08.05.2020E033.

YAN Zenghao,ZHANG Weijian,WU Hao,et al.Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(03):12-18. DOI： 10.13471/j.cnki.acta.snus.2020.08.05.2020E033.

摘要

脑心通胶囊是由黄芪、丹参等十六味中药组成的复方中药大品种，具有益气活血、化瘀通络的功效。临床上主要用于治疗心脑血管疾病，疗效确切。大量临床研究和基础研究均表明，脑心通胶囊具有抗血小板聚集、抗血栓、抗炎、抗动脉粥样硬化、改善代谢紊乱等广泛的药效作用。代谢紊乱是大部分心脑血管疾病的共同病理基础和危险因素，本文就脑心通胶囊物质基础及改善代谢紊乱相关疾病方面的研究进展进行综述，为其揭示科学内涵以及拓展临床应用提供新思路。

Abstract

Naoxintong Capsule is a traditional Chinese medicine formulation composed of 16 traditional Chinese medicines， such as

Astragali Radix

（Huangqi） and

Salviae miltiorrhizae

Radix

Rhizoma

（Danshen）. It is clinically used to treat cardiovascular and cerebrovascular diseases with the functions of benefiting qi for activating blood circulation and promoting blood circulation for removing obstruction in collaterals. A number of clinical and basic studies have shown that Naoxintong Capsule possesses extensive pharmacological activities， such as anti-platelet aggregation， anti-thrombus， anti-inflammation， anti-atherosclerosis and improving metabolic disturbance. Metabolic disturbance is a common risk factor and causes most of cardiovascular and cerebrovascular diseases. This article reviewed the progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance and its related diseases， and proposed perspectives for its scientific intension and clinical application.

关键词

脑心通胶囊物质基础代谢紊乱心脑血管疾病作用机制

Keywords

Naoxintong Capsulematerial basismetabolic disturbancecardiovascular and cerebrovascular diseaseseffects and mechanisms

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