海南东寨港红树林内生真菌<italic style="font-style: italic">Aspergillus fumigatus </italic>SAS10吡喃酮类代谢产物

郭思雨; 邹庭光; 朱静琳; 林慧美; 许婉毅; 黄洪波; 陶移文

doi:10.13471/j.cnki.acta.snus.2020.01.09.2020E001

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海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物

研究论文 | 更新时间：2023-11-01

- 海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物
- Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan
- 中山大学学报(自然科学版) 2020年59卷第4期页码：19-23
- 作者机构：
  
  广州医科大学药学院分子靶标和临床药理重点实验室/ 广州医科大学附属第五医院，广东广州 511436
- 作者简介：
  
  郭思雨（1995年生），女；研究方向：天然药物化学；E-mail: 654512404@qq.com
  陶移文（1975年生），男；研究方向：天然药物化学；E-mail: yywentao@aliyun.com
- 基金信息：
  
  广东省自然科学基金(2018A0303130201;2016A030313588);广州医科大学大学生实验室开放项目(广医大发【2018】27号No.14);广东省大学生创新训练项目立项项目(201810570078;pdjh2020b0487);广州医科大学大学生创新项目立项项目(2017A079;2018A103;2018A107)
- DOI：10.13471/j.cnki.acta.snus.2020.01.09.2020E001
  中图分类号： O621.2
- 纸质出版日期：2020-07-20，
  
  收稿日期：2020-01-09，
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郭思雨,邹庭光,朱静琳等.海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物[J].中山大学学报(自然科学版),2020,59(04):19-23.

GUO Siyu,ZOU Tingguang,ZHU Jinglin,et al.Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2020,59(04):19-23.
郭思雨,邹庭光,朱静琳等.海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物[J].中山大学学报(自然科学版),2020,59(04):19-23. DOI： 10.13471/j.cnki.acta.snus.2020.01.09.2020E001.

GUO Siyu,ZOU Tingguang,ZHU Jinglin,et al.Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2020,59(04):19-23. DOI： 10.13471/j.cnki.acta.snus.2020.01.09.2020E001.

摘要

采用大米培养基，对无瓣海桑内生真菌

Aspergillus fumigatus

SAS10进行静置发酵，运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、以及半制备高效液相等分离手段对发酵产物进行分离纯化，获得7个化合物。经分析质谱、核磁等波谱数据，并通过与文献对比鉴定化合物为：aspergyllone（

），（

）-2-（羟基（苯基）甲基）-4H-吡喃-4-酮（

），carbonarone A（

）， campyrone A（

），campyrone C（

），asperfurandione A（

）和 dibutylterephthalate（

）。所得7个化合物均为首次报道为烟曲霉次级代谢产物。

Abstract

The mangrove endophytic fungus

Aspergillus fumigatus

SAS10 from

Sonneratia apetala

of Dongzhai haror in Hainan was fermented by using rice medium. The extract of fermentation culture was subjected to column chromatography on silica gel

column chromatography on Sephadex LH-20

and semi-preparative HPLC. Seven compounds were obtained.By analyzing mass and NMR spectroscopic data

their structures were identified as aspergyllone (

)

(

)-2-(hydroxy(phenyl)methyl)-4H-pyran-4-one (

)

carbonarone A (

)

campyrone A (

)

campyrone C (

)

asperfurandione A (

) and dibutylterephthalate (

)

respectively. All of compounds obtained are reported firstly from secondary metabolites of the mangrove endophytic fungus

Aspergillus fumigatus

关键词

红树林内生真菌Aspergillus fumigatus次级代谢产物吡喃酮类化合物

Keywords

mangroveendophytic fungusAspergillus fumigatussecondary metabolitespyrone

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海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物

Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan

DOI：10.13471/j.cnki.acta.snus.2020.01.09.2020E001

摘要

Abstract

关键词

Keywords

references