LIU Chunyan, WEI Xuemei, FENG Zhaoyong, et al. Existence and uniqueness of global solution for the treatment model of cancer vaccine and checkpoint inhibitor[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2019,58(3):94-102.
LIU Chunyan, WEI Xuemei, FENG Zhaoyong, et al. Existence and uniqueness of global solution for the treatment model of cancer vaccine and checkpoint inhibitor[J]. Acta Scientiarum Naturalium Universitatis SunYatseni, 2019,58(3):94-102. DOI: 10.13471/j.cnki.acta.snus.2019.03.012.
A combined treatment model of cancer vaccine and checkpoint inhibitor
which contains nine coupled reaction diffusion equations
is studied. By using the Banach fixed point theorem and
L
p
theory of parabolic equation
the existence and uniqueness of the model in the local solution is proved. And then the existence and uniqueness of the global solution is obtained by using the extension method.
关键词
癌症疫苗检查点抑制剂联合治疗局部解整体解存在唯一性
Keywords
cancer vaccinecheckpoint inhibitorcombined treatmentlocal solutionglobal solutionexistence and uniqueness