Heterogeneous network (Het Net) is a typical network structure of the future mobile communication system. And the uplink power control algorithm is of an important technology in the interference management of Het Net. Combining the game theory and the uplink power control algorithm of Het Net , a new uplink power control algorithm of game theory in Het Net is proposed in this paper. The new algorithm applies the price payment function of game theory to the uplink power and power allocation algorithm. In Het Net, any user’s power change should consider the generating interference to the other co-frequency users located in the network and use it as a price-based payment function to control the user uplink power. After multiple iterations, the optimal users‘ uplink power can be obtained which results in the improvement of network performance. Simulation results show that the proposed algorithm can bring the performance gains of Het Net in both the system uplink throughput and energy efficiency ratio.