Based on the Support Vector Machine algorithm, the proteinprotein interactions (PPI) networks between Par-4, the cancerrelated apoptosis protein, and related proteins have been built. There are 82 proteins have been predicted interacting with Par-4. The proteins are classified into eight groups by biological functions, which include protein kinase, death receptor associate factor, ubiquitinprotein ligase, special disease associate proteins, DNA replication related proteins, special structure associate protein, regulatory protein and others. Combined with literatures mining and molecular chaperones of Par-4 searching from BOND database, two new signal transduction pathways of Par-4 have been deduced. In this paper, we first discover that Par-4 interacts with a group of ubiquitinproteins. We find that Par-4 has complicated interactions with many proteins. Par-4 plays a major role in some apoptosis pathways.