Ethyl-hydroxyimino-bromopropanoate was prepared from ethyl lactate

NBS and hydroxylamine hydrochloride in a novel method. In the reaction process

intermediate ethyl bromopyruvate was obtained by bromination and oxidation

instead of being separated from the reaction mixture and directly used to react with hydroxylamine hydrochloride in CHCl

3

and CH

3

OH solution. The white crystal product was obtained in 48% yield. The new derivative ethyl-3-bromo-2-(1-naphthoyl-oximino) propanoate was synthesized successfully

via

the mild esterification reaction. The target compound was characterized by

1

HNMR

13

C-NMR and elemental analysis.