This paper takes 21 regions in Guangdong province as research object，and uses the index of per capita GDP to analyse spatialtemporal evolution of the economic development during 2000-2012 and 2018 in Guangdong Province by means of grey prediction，spatial autocorrelation and spatial regression. The characteristic of global spatial autocorrelation of the economic development level of different regions in Guangdong is obvious and the region difference of economic development in Guangdong is relatively small. The spatial pattern of region economic development in Guangdong is stable and the spatial difference is relatively small. The local spatial autocorrelation of the economic development level of different regions in Guangdong is not obvious and different gather centers have been formed. The spatial difference of economic development is influenced mainly by economic structure，urbanization economic development level and human resources．