The Lie symmetry and the conserved quantity of fractional Lagrange system based on El-Nabulsi models are studied. Firstly, the D-Alembert-Lagrange principle of the El-Nabulsi models is deduced based on the fractional action-like variational problem which is expanded by the Riemann-Liouville integral, and the differential equations of motion of the system are obtained. Secondly, the definition and the criterion of the Lie symmetry are given, the determination equations of the Lie symmetry of the system are established, and the generalized Hojman theorem is put forward. At the same time, the existence condition and the form of the generalized Hojman conserved quantity are obtained. Then, the generalized Noether theorem is established, the existence condition and the form of the Noether conserved quantity led by the Lie symmetry are given. Finally, two examples are given to illustrate the application of the results.