The pollution characteristics and determinants of the atmospheric particulates and its determinants in Guiyang were studied through sorting and statistical analysis of the data of PM_2.5PM₁₀and meteorological series of Guiyang during 2014-2015, together with assessing of their interaction. The result showed that PM_2.5was the main cause of atmospheric particulate matter in Guiyang, which possessed typical winterspring and summerfall seasonal characteristics. While the average of daily concentration of PM_2.5was 28.79 μg·m^-3in summer, which was fluctuated between 13 to 68μg·m^-3. It was increased to 60.64 μg·m^-3in winter, which ranged from 15 to 127 μg·m^-3. According to the ambient air quality standard (GB3095-2012), the over standard rate of PM_2.5in spring, summer, fall and winter was 4.4%, 0, 5.5% and 5.5%, respectively. The daily distribution of PM_2.5and PM₁₀demonstrated a “twin peaks”, the first one of which occurred at 10:00 - 13:00, and it came earliest in summer while latest in winter the second peak occurred at 20:00 - 23:00, the first one of which came earliest in spring while latest in summer. This difference was mainly resulted from the change of season solar radiation and human daily routine. The spatial distribution of PM_2.5showed roughly gradual reduction from urban to rural, the average of which was ordered as Shihuanbaozhan > Yejinting > Huaxi district > Xiaohe district > Hongbianmen > Maanshan > Wudang district > Tongmuling in winter, while the order was Hongbianmen > Yejinting > Xiaohe district > Shihuanbaozhan > Huaxi district > Wudang district > Maanshan > Tongmuling while in summer. Meteorological conditions played a dominant role in atmospheric particulate matter pollution, which was followed by human activities and the local geographical environment.