This paper mainly discusses the characteristics and factors that influence space-time paths of middle-class daily activities, using the time geography and multilevel clustering methods, on the basis of the questionnaire survey on the working and weekend day activity diaries of 881 middle classes in 36 middle-class neighborhoods. The results show that the activity paths of middle class have differential forms on the working day according to the work locations, and can be clustered into 5 types including the straight path without work and other curve paths with stable jobs but different commuting distance. While, the activity paths of middle class have diversified forms on the weekend day according to the activity distances and durations, and can be clustered into 6 types such as curve path with short distance, middle-short distance of middle-class shopping and dining primarily, middle-long distance of middle-class shopping and errands primarily, and long distance of middle-class leisure and dinning primarily from home, etc. In addition, the characteristics of activity paths are various with different natural, socioeconomic and environmental middle classes. On the whole, the individual futures, urban space structure, industrial and institutional factors comprehensively play a vital role on the daily activities of middle classes, which lead to the space-time paths of those having unique characteristics. The study on the spacetime paths of middle-class daily activities contributes to reveal the daily routine of the middle class, and provides important basis for urban socioeconomic dynamic and urban refined management.