The metabolites from mangrove endophytic fungus <italic style="font-style: italic">Talaromyces amestolkiae</italic> 30

LIU Hongliang; ZHAO Fei; TANG Fengting; LI Jinjun; ZHANG Xuan; DU Zhiyun; HUANG Huarong; SHE Zhigang

doi:10.13471/j.cnki.acta.snus.2023E048

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The metabolites from mangrove endophytic fungus Talaromyces amestolkiae 30

Research articles | 更新时间：2024-04-10

- The metabolites from mangrove endophytic fungus Talaromyces amestolkiae 30
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 63, Issue 2, Pages: 160-167(2024)
- 作者机构：
  
  1.广东工业大学生物医药学院，广东广州 510006
  2.中山大学化学学院，广东广州 510006
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2023E048
  CLC： O629.9
- Published：25 March 2024，
  
  Published Online：08 January 2024，
  
  Received：14 October 2023，
  
  Accepted：30 November 2023
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刘洪亮,赵飞,唐凤婷等.红树植物桐花树内生真菌Talaromycesamestolkiae 30的次生代谢产物[J].中山大学学报(自然科学版)(中英文),2024,63(02):160-167.

LIU Hongliang,ZHAO Fei,TANG Fengting,et al.The metabolites from mangrove endophytic fungus Talaromyces amestolkiae30[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2024,63(02):160-167.
刘洪亮,赵飞,唐凤婷等.红树植物桐花树内生真菌Talaromycesamestolkiae 30的次生代谢产物[J].中山大学学报(自然科学版)(中英文),2024,63(02):160-167. DOI： 10.13471/j.cnki.acta.snus.2023E048.

LIU Hongliang,ZHAO Fei,TANG Fengting,et al.The metabolites from mangrove endophytic fungus Talaromyces amestolkiae30[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2024,63(02):160-167. DOI： 10.13471/j.cnki.acta.snus.2023E048.

摘要

对红树植物桐花树内生真菌

Talaromyces

amestolkiae

30的次级代谢产物进行了研究。采用大米固体发酵培养，色谱分离技术纯化单体，ESIMS和NMR等波谱数据分析，鉴定了12个异香豆素单体化合物：aspergillumarin A（

）、aspergillumarin B（

）、 5，6-dihydroxy-3-（4-hydroxypentyl）-isochroman-1-one（

）、 mucorisocoumarin A（

）、 peniisocoumarin H（

）、 peniisocoumarin E（

）、 dichlorodiaportin（

）、 mucorisocoumarin C（

）、 peniisocoumarin G（

）、 talumarin A（

）、 5，6，8-trihydroxy-4-（1'-hydroxyethyl）-isocoumarin（

）和sescandelin（

），其中化合物

、

首次从篮状属真菌中分离得到。二倍稀释法抑菌活性测试显示，化合物

、

有抑制金黄色葡萄球菌作用；MTT法测试细胞毒活性，表明化合物

对前列腺癌PC-3细胞和VCaP细胞有细胞毒活性。

Abstract

The metabolites of the endophytic fungus

Talaromyces amestolkiae

30 from the mangrove plant

Aegiceras corniculatum

(L.) Blanco were investigated. The fungus was cultured in rice medium

the monomeric compounds were isolated and purified by the chromatographic technique

and the structures of the compounds were identified by analysis of spectroscopy such as ESIMS and NMR. Twelve known analogues of isocoumarins (

) were isolated and identified as aspergillumarin A (

)

aspergillumarin B (

)

6-dihydroxy-3-(4-hydroxypentyl)-isochroman-1-one (

)

mucorisocoumarin A (

)

peniisocoumarin H (

)

peniisocoumarin E (

)

dichlorodiaportin (

)

mucorisocoumarin C (

)

peniisocoumarin G (

)

talumarin A (

)

8-trihydroxy-4-(1'-hydroxyethyl)-isocoumarin (

) and sescandelin (

). Among them

compounds

and

were obtained from the genus Talaromyces for the first time. The antibacterial activities of these compounds were tested in vitro using the twofold dilution method. Compounds

and

showed inhibitory activity against

Staphylococcus aureus

. The cytotoxic activity was tested by the MTT assay. Compound 7 showed cytotoxicity against prostate cancer PC-3 cells and VCaP cells.

关键词

红树林真菌篮状菌次级代谢产物异香豆素类

Keywords

mangrove fungusTalaromycesamestolkiaesecondary metabolitesisocoumarin

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Related Institution

Institute of Marine Drugs / College of Pharmacy， Guangxi University of Chinese Medicine

Guangxi Zhuang Yao Medicine Center of Engineering and Technology

School of Chemistry and Pharmacy， Guangxi Normal University

School of Life Sciences， Sun Yat-sen University

Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University

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The metabolites from mangrove endophytic fungus Talaromyces amestolkiae 30

DOI：10.13471/j.cnki.acta.snus.2023E048

摘要

Abstract

关键词

Keywords

references