The metabolites of an endophytic fungus <italic style="font-style: italic">Fusarium lateritium</italic> ZMT01 from <italic style="font-style: italic">Oxya chinensis </italic>Thunberg

FANG Haodong; HUANG Zihui; LI Suning; LI Yangqian; SHE Zhigang; XIONG Yahong; LI Chunyuan

doi:10.13471/j.cnki.acta.snus.2023E036

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The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunberg

Research articles | 更新时间：2024-01-25

- The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunberg
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 63, Issue 1, Pages: 71-77(2024)
- 作者机构：
  
  1.华南农业大学材料与能源学院 / 生物基材料与能源教育部重点实验室，广东广州 510642
  2.中山大学化学学院，广东广州 510275
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2023E036
  CLC： O629
- Published：25 January 2024，
  
  Published Online：23 October 2023，
  
  Received：10 July 2023，
  
  Accepted：01 September 2023
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房豪东,黄子辉,李苏柠等.一株中华稻蝗内生真菌Fusarium lateritium ZMT01的代谢产物[J].中山大学学报(自然科学版)(中英文),2024,63(01):71-77.

FANG Haodong,HUANG Zihui,LI Suning,et al.The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunberg[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2024,63(01):71-77.
房豪东,黄子辉,李苏柠等.一株中华稻蝗内生真菌Fusarium lateritium ZMT01的代谢产物[J].中山大学学报(自然科学版)(中英文),2024,63(01):71-77. DOI： 10.13471/j.cnki.acta.snus.2023E036.

FANG Haodong,HUANG Zihui,LI Suning,et al.The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunberg[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2024,63(01):71-77. DOI： 10.13471/j.cnki.acta.snus.2023E036.

摘要

研究一株中华稻蝗内生真菌

Fusarium lateritium

ZMT01的代谢产物，采用大米培养基发酵真菌，色谱技术分离纯化单体，波谱分析鉴定结构，共从发酵物中分离鉴定了10个化合物：fusopoltide A （

）、fusopoltide B （

）、fusopoltide D （

）、solaniol （

）、javanicin （

）、（1

， 4

， 10

）-3，4-dihydro-6，9-dihydroxy-8-methoxy-10-（2-oxopropyl）-1，4-methano-2-benzoxepin-5 （1

）-one （

）、2，2′‐methylenebis（4‐methyl‐6‐tert‐butylphenol）（

）、2-hydroxymethyl-5-isopropoxy-4-methoxynaphthalen （

）、

-sitosterol （

）和walterolactone A （

）。其中化合物

、

为首次从

Fusarium

属中得到，除化合物

外，其他化合物为首次从

Fusarium lateritium

中分离到。采用二倍稀释法测试抗菌活性，结果显示化合物

和

对O6血清型大肠杆菌

Escherichia coli

有强抑制活性，MIC为6.25 µg/mL，化合物

对尖孢镰孢菌

Fusarium oxysporum

显示中等抑菌活性，MIC为200 µg/mL。

Abstract

The metabolites of an endophytic fungus

Fusarium lateritium

ZMT01 from

Oxya chinensis

Thunbergwere investigated. The fungus was cultured in rice medium， the monomeric compounds were isolated and purified by the chromatographic technique， and the structures of compounds were identified by analysis of spectroscopy. Ten compounds were isolated and identified as fusopoltide A （

）， fusopoltide B （

）， fusopoltide D （

）， solaniol （

）， javanicin （

），（1

， 4

， 10

）-3， 4-dihydro-6，9-dihydroxy-8-methoxy-10-（2-oxopropyl）-1，4-methano-2-benzoxepin-5 （1

）-one （

）， 2，2′‐methylenebis（4‐methyl‐6‐tert‐butylphenol）（

）， 2-hydroxymethyl-5-isopropoxy-4-methoxynaphthalen （

），

-sitosterol （

） and walterolactone A （

）. Among them， compounds

and

were firstly obtained from the genus

Fusarium

， and all of them except compound

were isolated from

Fusarium lateritium

for the first time. The antibacterial activities of these compounds were tested in vitro using the two-fold dilution method. Compounds

and

showed a high inhibitory activity against

Escherichia coli

with serotype O6 with MIC of 6.25 µg/mL， and compound

showed a moderate inhibitory activity against

Fusarium oxysporum

with MIC of 200 µg/mL.

关键词

内生真菌砖红镰刀菌代谢产物抗菌活性

Keywords

endophytic fungiFusarium lateritiummetabolitesantibacterial activity

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Related Author

CHEN Ruolan

LI Ziyang

WU Huizhen

LUO Yimeng

SHE Zhigang

XIONG Yahong

LI Chunyuan

Chunyuan LI

Related Institution

Key Laboratory for Biobased Materials and Energy of Ministry of Education / College of Materials and Energy， South China Agricultural University

Key Laboratory for Biobased Materials and Energy of Ministry of Education / College of Materials and Energy， South China Agricultural University Guangzhou

School of Life Sciences and Biopharmaceutics， Guangdong Pharmaceutical University / Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances

Guangzhou Institute of Microbiology

School of Chemistry and Chemical Engineering, Sun Yatsen University

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The metabolites of an endophytic fungus Fusarium lateritium ZMT01 from Oxya chinensis Thunberg

DOI：10.13471/j.cnki.acta.snus.2023E036

摘要

Abstract

关键词

Keywords

references