Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus <italic style="font-style: italic">Aspergillus</italic> sp. GXIMD00016

XIAO Ze′en; HUANG Xishan; WEI Weixuan; LU Wuling; TAN Zhen; LIU Yonghong

doi:10.13471/j.cnki.acta.snus.2022E006

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Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus Aspergillus sp. GXIMD00016

Research articles | 更新时间：2023-11-01

- Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus Aspergillus sp. GXIMD00016
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 61, Issue 6, Pages: 69-73(2022)
- 作者机构：
  
  1.广西中医药大学海洋药物研究院 / 药学院，广西南宁 530200
  2.广西壮瑶药工程技术研究中心，广西南宁 530200
  3.广西师范大学化学与药学学院，广西桂林 541000
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2022E006
  CLC： O629.9
- Published：25 November 2022，
  
  Published Online：30 March 2022，
  
  Received：18 February 2022，
  
  Accepted：08 March 2022
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肖泽恩,黄锡山,韦蔚烜等.北海红树林内生真菌Aspergillus sp. GXIMD00016的抗炎次级代谢产物[J].中山大学学报(自然科学版),2022,61(06):69-73.

XIAO Ze′en,HUANG Xishan,WEI Weixuan,et al.Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus Aspergillus sp. GXIMD00016[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(06):69-73.
肖泽恩,黄锡山,韦蔚烜等.北海红树林内生真菌Aspergillus sp. GXIMD00016的抗炎次级代谢产物[J].中山大学学报(自然科学版),2022,61(06):69-73. DOI： 10.13471/j.cnki.acta.snus.2022E006.

XIAO Ze′en,HUANG Xishan,WEI Weixuan,et al.Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus Aspergillus sp. GXIMD00016[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(06):69-73. DOI： 10.13471/j.cnki.acta.snus.2022E006.

摘要

采用大米培养基对红树内生真菌

Aspergillus

sp. GXIMD00016进行规模发酵，利用层析技术对发酵产物进行分离纯化，获得7个化合物。经波谱技术鉴定结构，并通过与文献对比鉴定化合物为aculeatusquinone A（

）、aculeatusquinone C（

）、roseopurpurin A（

）、myxotrichin C（

）、2，7-didechlorovicanic（

）、atraric acid（

）和2，5-dimethyl-1，3-benzenediol（

），其中化合物

为新天然产物，化合物

和

为首次从曲霉菌属中获得。首次考察化合物

～

和

～

对脂多糖（lipopolysaccharide，LPS）诱导RAW 264.7细胞产生NO的抑制作用，化合物

～

具有显著抗炎作用，IC

值为16.68～28.15 μmol/L。

Abstract

The mangrove endophytic fungus

Aspergillus

sp. GXIMD00016 was fermented by using rice medium. The metabolites were isolated by the chromatography technology and seven compounds were obtained. By analyzing MS and NMR spectroscopic data，their structures were identified as aculeatusquinone A

（1

）， aculeatusquinone C （

）， roseopurpurin A （

）， myxotrichin C （

）， 2，7-didechlorovicanic （

）， atraric acid （

） and 2，5-dimethyl-1，3-benzenediol （

）. Besides， compound

was a new natural product， and compounds

and

were isolated from

Aspergillus

sp. for the first time. The inhibitory effects of compounds

and

on lipopolysaccharide （LPS） induced NO production were evaluated in mouse macrophage RAW264.7 cells. The results showed that compounds

had a significant anti-inflammatory activity with IC

values ranging from 16.68 to 28.15 μmol/L.

关键词

红树内生真菌次级代谢产物曲霉抗炎苯醌

Keywords

mangrove endophytic fungussecondary metabolitesAspergillusanti-inflammatorybenzoquinone

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Related Author

Ze′en XIAO

Xishan HUANG

Weixuan WEI

Wuling LU

Zhen TAN

Yonghong LIU

LIN Shao′e

SHE Zhigang

Related Institution

School of Life Sciences， Sun Yat-sen University

School of Chemistry， Sun Yat-sen University

School of Biomedicine， Guangdong University of Technology

Key Laboratory for Biobased Materials and Energy of Ministry of Education / College of Materials and Energy， South China Agricultural University

Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University

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Anti-inflammatory secondary metabolites from a Beihai mangrove endophytic fungus Aspergillus sp. GXIMD00016

DOI：10.13471/j.cnki.acta.snus.2022E006

摘要

Abstract

关键词

Keywords

references