The dimeric xanthones of mangrove endophytic fungus <italic style="font-style: italic">Aspergillus </italic>sp. HNY16-5B isolated from <italic style="font-style: italic">Sonneratia apetala</italic>

LIU Yayue; WU Yinnan; SHE Zhigang

doi:10.13471/j.cnki.acta.snus.2021C025

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The dimeric xanthones of mangrove endophytic fungus Aspergillus sp. HNY16-5B isolated from Sonneratia apetala

Research articles | 更新时间：2023-11-01

- The dimeric xanthones of mangrove endophytic fungus Aspergillus sp. HNY16-5B isolated from Sonneratia apetala
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 61, Issue 5, Pages: 76-83(2022)
- 作者机构：
  
  1.广东海洋大学食品科技学院，广东湛江 524088
  2.中山大学化学学院，广东广州 510006
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2021C025
  CLC： O621.2
- Published：25 September 2022，
  
  Published Online：21 January 2022，
  
  Received：04 November 2021，
  
  Accepted：15 December 2021
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刘亚月,吴颖楠,佘志刚.无瓣海桑来源内生真菌Aspergillus sp.HNY16-5B中的二聚呫吨类化合物[J].中山大学学报(自然科学版),2022,61(05):76-83.

LIU Yayue,WU Yinnan,SHE Zhigang.The dimeric xanthones of mangrove endophytic fungus Aspergillus sp. HNY16-5B isolated from Sonneratia apetala[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(05):76-83.
刘亚月,吴颖楠,佘志刚.无瓣海桑来源内生真菌Aspergillus sp.HNY16-5B中的二聚呫吨类化合物[J].中山大学学报(自然科学版),2022,61(05):76-83. DOI： 10.13471/j.cnki.acta.snus.2021C025.

LIU Yayue,WU Yinnan,SHE Zhigang.The dimeric xanthones of mangrove endophytic fungus Aspergillus sp. HNY16-5B isolated from Sonneratia apetala[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(05):76-83. DOI： 10.13471/j.cnki.acta.snus.2021C025.

摘要

研究了海南红树植物无瓣海桑

Sonneratia apetala

来源内生真菌

Aspergillus

sp.（HNY16-5B）的次级代谢产物。利用察氏培养基对该菌株进行发酵培养，并综合运用正、反相硅胶柱层析，Sephadex LH-20凝胶和重结晶等分离手段，从中分离获得了5个二聚呫吨化合物（

）。运用MS和1D、2D NMR等现代波谱技术，并与文献数据对比，鉴定为：asperpyrone B （

）、fonsecinone A （

）、aurasperone A （

）、asperpyrone A （

）和dianhydroaurasperone C （

）。通过培养成功获得了化合物

的单晶，并利用铜靶X-Ray单晶衍射技术确定其轴手性为

。通过对比CD谱，最终确定了化合物

的轴手性均为

。

Abstract

The secondary metabolites of endophytic fungus

Aspergillu

s sp. （HNY16-5B）， isolated from the leaves of the mangrove plant

Sonneratia apetala

， were studied. The strain was fermented and cultured with czapek′s medium， and then subjected to silica gel column chromatography， Sephadex LH-20， ODS， and recrystallization. Five dimerxanthones： asperpyrones B （

）， fonsecinone A （

）， aurasperone A （

）， asperpyrones A （

） and dianhydroaurasperone C （

） were identified using modern spectroscopy techniques such as MS and 1D， 2D NMR， and comparing with literature data. The single crystal of compound

was successfully obtained by culturing， whose axial chirality was further confirmed to

by single-crystal X-Ray diffraction experiment using Cu K

radiation. By comparing the CD spectra， it was determined that the axial chirality of compounds

were

关键词

红树林内生真菌Aspergillus sp.次级代谢产物二聚呫吨

Keywords

mangroveendophytic fungusAspergillus sp.secondary metabolitedimer xanthones

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Related Author

Yayue LIU

Yinnan WU

Zhigang SHE

LIU Yayue

FENG Yunkai

YANG Wencong

Yayue LIU

Yunkai FENG

Related Institution

Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University

School of Chemical Engineering and Light Industry, Guangdong University of Technology

School of Life Sciences, Sun Yat-sen University

School of Chemistry and Chemical Engineering,Sun Yat-sen University

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The dimeric xanthones of mangrove endophytic fungus Aspergillus sp. HNY16-5B isolated from Sonneratia apetala

DOI：10.13471/j.cnki.acta.snus.2021C025

摘要

Abstract

关键词

Keywords

references