Nitrogen-contained metabolites of a mangrove endophytic fungus <italic style="font-style: italic">Aspergillus</italic> sp. HNY16-5C from Hainan

XIAO Ze′en; LIN Shao′e; SHE Zhigang; LU Yongjun; TAN Zhen; LIU Yonghong

doi:10.13471/j.cnki.acta.snus.2021C013

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Nitrogen-contained metabolites of a mangrove endophytic fungus Aspergillus sp. HNY16-5C from Hainan

Research articles | 更新时间：2023-11-01

- Nitrogen-contained metabolites of a mangrove endophytic fungus Aspergillus sp. HNY16-5C from Hainan
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 61, Issue 4, Pages: 65-69(2022)
- 作者机构：
  
  1.广西中医药大学海洋药物研究院 / 药学院，广西南宁 530200
  2.广西壮瑶药工程技术研究中心，广西南宁 530200
  3.中山大学化学学院，广东广州 510275
  4.中山大学生命科学学院，广东广州 510275
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2021C013
  CLC： O629.9
- Published：25 July 2022，
  
  Published Online：12 November 2021，
  
  Received：01 July 2021，
  
  Accepted：31 July 2021
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肖泽恩,林少娥,佘志刚等.海南红树林内生真菌Aspergillus sp. HNY16-5C的含氮类次级代谢产物[J].中山大学学报(自然科学版),2022,61(04):65-69.

XIAO Ze′en,LIN Shao′e,SHE Zhigang,et al.Nitrogen-contained metabolites of a mangrove endophytic fungus Aspergillus sp. HNY16-5C from Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(04):65-69.
肖泽恩,林少娥,佘志刚等.海南红树林内生真菌Aspergillus sp. HNY16-5C的含氮类次级代谢产物[J].中山大学学报(自然科学版),2022,61(04):65-69. DOI： 10.13471/j.cnki.acta.snus.2021C013.

XIAO Ze′en,LIN Shao′e,SHE Zhigang,et al.Nitrogen-contained metabolites of a mangrove endophytic fungus Aspergillus sp. HNY16-5C from Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(04):65-69. DOI： 10.13471/j.cnki.acta.snus.2021C013.

摘要

采用大米培养基对红树内生真菌

Aspergillus

sp. HNY16-5C进行规模发酵，利用层析技术对发酵产物进行分离纯化，获得6个含氮类化合物。经波谱技术鉴定结构，并通过与文献对比鉴定化合物为brevianamide K（

）、brevianamide V（

）、（

）-brevianamide Q（

）、（

）-brevianamide R（

）、（±）-asperginulin A（

）和brevianamide M（

）。对化合物

～

首次进行抗结核活性测试，结果显示化合物

对结核杆菌的酪氨酸磷酸酶B（MptpB酶）显示有较强的抑制活性，IC

为（7.07±2.76） μmol/L。

Abstract

The mangrove endophytic fungus

Aspergillus

sp. HNY16-5C was fermented by using rice medium. The metabolites were isolated by the chromatography technology. Six nitrogen-contained compounds were obtained. By analyzing MS and NMR spectroscopic data，their structures were identified as brevianamide K（

）， brevianamide V（

），（

）-brevianamide Q（

），（

）-brevianamide R（

），（±）-asperginulin A（

） and brevianamide M（

）， respectively. Compound

exhibited potent inhibitory effect against

Mycobacterium tuberculosis

protein tyrosine phosphatase B（MptpB） with IC

values of （7.07 ± 2.76） μmol/L.

关键词

红树内生真菌次级代谢产物含氮类化合物MptpB酶

Keywords

mangrove endophytic fungussecondary metabolitesnitrogen-contained compoundsMptpB

references

World Health Organization. Global tuberculosis report 2020［EB/OL］. Geneva： World Health Organization， 2020. （2020-10-14）［2021-07-01］. https：//apps.who.int/iris/bitstream/handle/10665/336069/978924001 3131-eng.pdf？sequence=1&isAllowed=yhttps://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf?sequence=1&isAllowed=y.

HUANG X S， HUANG H B， LI H X， et al. Asperterpenoid A， a new sesterterpenoid as an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B from the culture of Aspergillus sp.16-5c［J］. Organic Letters， 2013， 15（4）： 721-723.

MÜLLER A N， WILK W， SAXENA K， et al. Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis［J］. Angewandte Chemie International Edition， 2008， 47（32）： 5973-5977.

MONTALIBET J， SKOREY K I， KENNEDY B P. Protein tyrosine phosphatase： Enzymatic assays［J］. Methods， 2005， 35（1）：2-8.

SONG F H， LIU X R， HUI G， et al. Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor［J］. Organic Letters， 2012， 14（18）：4770-4773.

LIU W， WANG L P， WANG B， et al. Diketopiperazine and diphenylether derivatives from marine algae-derived Aspergillus versicolor OUCMDZ-2738 by epigenetic activation［J］. Marine Drugs， 2018， 17（1）：6.

CAI R L， JIANG H M， XIAO Z E， et al. （－）- and （+）-Asperginulin A， a pair of indole diketopiperazine alkaloid dimers with a 6/5/4/5/6 pentacyclic skeleton from the mangrove endophytic fungus Aspergillus sp. SK-28［J］. Organic letters， 2019， 21（23）：9633-9636.

LI G Y， YANG T， LUO Y G， et al. Brevianamide J， a new indole alkaloid dimer from fungus Aspergillus versicolor［J］. Organic Letters， 2009， 11（16）：3714-3717.

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Related Author

Ze′en XIAO

Shao′e LIN

Zhigang SHE

Yongjun LU

Zhen TAN

Yonghong LIU

HUANG Xishan

WEI Weixuan

Related Institution

School of Chemistry and Pharmacy， Guangxi Normal University

School of Biomedicine， Guangdong University of Technology

Key Laboratory for Biobased Materials and Energy of Ministry of Education / College of Materials and Energy， South China Agricultural University

Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University

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Nitrogen-contained metabolites of a mangrove endophytic fungus Aspergillus sp. HNY16-5C from Hainan

DOI：10.13471/j.cnki.acta.snus.2021C013

摘要

Abstract

关键词

Keywords

references