Network pharmacology analysis of Compound Xueshuantong Capsule （CXC） in improving microcirculation

BI Cong; WU Hao; WANG Yonggang; PENG Wei; SU Weiwei; LIU Hong

doi:10.13471/j.cnki.acta.snus.2020E024

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Network pharmacology analysis of Compound Xueshuantong Capsule （CXC） in improving microcirculation

Research articles | 更新时间：2023-11-01

- Network pharmacology analysis of Compound Xueshuantong Capsule （CXC） in improving microcirculation
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 61, Issue 2, Pages: 65-75(2022)
- 作者机构：
  
  中山大学生命科学学院 / 广东省中药上市后质量与药效再评价工程技术研究中心，广东广州 510275
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2020E024
  CLC： R285
- Published：25 March 2022，
  
  Published Online：22 April 2021，
  
  Received：24 June 2020，
  
  Accepted：30 September 2020
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毕聪,吴灏,王永刚等.基于网络药理学解析复方血栓通胶囊改善微循环的作用机制[J].中山大学学报(自然科学版),2022,61(02):65-75.

BI Cong,WU Hao,WANG Yonggang,et al.Network pharmacology analysis of Compound Xueshuantong Capsule （CXC） in improving microcirculation[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(02):65-75.
毕聪,吴灏,王永刚等.基于网络药理学解析复方血栓通胶囊改善微循环的作用机制[J].中山大学学报(自然科学版),2022,61(02):65-75. DOI： 10.13471/j.cnki.acta.snus.2020E024.

BI Cong,WU Hao,WANG Yonggang,et al.Network pharmacology analysis of Compound Xueshuantong Capsule （CXC） in improving microcirculation[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(02):65-75. DOI： 10.13471/j.cnki.acta.snus.2020E024.

摘要

复方血栓通胶囊由三七、丹参、黄芪、玄参四味药材组成，具有活血化瘀、益气养阴的功效。本研究基于网络药理学技术，解析复方血栓通胶囊改善微循环的作用机制。通过GeneCards、OMIM、TCMSP数据库、Venny平台以及文献检索，筛选复方血栓通胶囊改善微循环的活性成分及潜在作用靶点；利用STRING、Cytoscape，构建PPI网络并筛选核心基因；通过DAVID、Cytoscape，对潜在靶点进行GO、KEGG分析并构建成分-靶点-通路网络。结果表明，筛选出复方血栓通胶囊改善微循环的活性成分41个，包括皂苷类、黄酮类、丹参酮类、丹酚酸类、环烯醚萜类以及苯丙素苷类成分；筛选出40个潜在作用靶点，核心靶点包括IL6、CCL2、ICAM1、EDN1、JUN、NOS3、PTGS2、VCAM1、MMP9和TNF；潜在作用靶点富集出的前20条通路主要包括Fluid shear stress and atherosclerosis、HIF-1 signaling pathway等血管相关通路，Complement and coagulation cascades、TNF signaling pathway等免疫炎症相关通路，Neuroactive ligand-receptor interaction等神经活性相关通路以及AGE-RAGE signaling pathway in diabetic complications等糖尿病相关通路。本研究揭示了复方血栓通胶囊可能通过调控心血管、炎症免疫、神经活性的相关靶点与通路，影响血管形成、血管舒张、血管平滑肌增生及微循环血流量，从而发挥改善微循环的作用。

Abstract

Compound Xueshuantong Capsule （CXC）， composed of Notoginseng Radix et Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma， Astragali Radix， and Scrophulariae Radix， has the functions of promoting blood circulation， removing blood stasis， benefiting qi and nourishing yin. This study was designed to analyze the mechanisms of CXC against microcirculation disorders based on the network pharmacology technology. The active components and potential targets of CXC to improve microcirculation was screened by GeneCards， OMIM， TCMSP databases， Venny， and literatures. The PPI network was constructed and the core genes were screened by STRING and Cytoscape. The GO and KEGG pathway were analyzed and the component-target-pathway network was established through DAVID and Cytoscape. The results showed that 41 active compounds and 40 potential targets of CXC were identified. Saponins， flavonoids， tanshinones， salvianolic acids， iridoids， and phenylpropanoid glycosides were the main active compounds. IL6， CCL2， ICAM1， EDN1， Jun， NOS3， PTGS2， VCAM1， MMP9 and TNF were the key targets. The first 20 pathways enriched by potential targets included cardiovascular pathways such as fluid shear stress and atherosclerosis pathway and HIF-1 signaling pathway； inflammatory pathways such as complement and coagulation cascades pathway and TNF signaling pathway， neuroactive pathways such as Neuroactive ligand-receptor interaction， and Diabetes related pathways such as AGE-RAGE signaling pathway. This study showed that CXC might play an important role in improving microcirculation by regulating the targets and pathways of cardiovascular， inflammation， immune， and neuroactivity， thus to affect the angiogenesis， vasodilation， proliferation of vascular smooth muscle and microcirculation blood flow.

关键词

复方血栓通胶囊网络药理学微循环作用机制

Keywords

Compound Xueshuantong Capsule （CXC）network pharmacologymicrocirculationmechanism

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