Metabolites of a mangrove fungus <italic style="font-style: italic">Fusarium</italic> sp. R5 under solid phase fermentation

DING Weijia; YE Juntao; SHE Zhigang; ZHONG Aiqing; LI Ziyang; LIN Longsheng; XIONG Yahong; LI Chunyuan

doi:10.13471/j.cnki.acta.snus.2020C020

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Metabolites of a mangrove fungus Fusarium sp. R5 under solid phase fermentation

Research articles | 更新时间：2023-11-01

- Metabolites of a mangrove fungus Fusarium sp. R5 under solid phase fermentation
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 60, Issue 5, Pages: 136-140(2021)
- 作者机构：
  
  1.生物基材料与能源教育部重点实验室 / 华南农业大学材料与能源学院，广东广州 510642
  2.中山大学化学学院，广东广州 510275
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2020C020
  CLC： O629.9
- Published：25 September 2021，
  
  Published Online：21 April 2021，
  
  Received：03 September 2020，
  
  Accepted：14 October 2020
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丁唯嘉,叶浚韬,佘志刚等.一株红树林真菌Fusarium sp. R5固相发酵代谢产物[J].中山大学学报(自然科学版),2021,60(05):136-140.

DING Weijia,YE Juntao,SHE Zhigang,et al.Metabolites of a mangrove fungus Fusarium sp. R5 under solid phase fermentation[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(05):136-140.
丁唯嘉,叶浚韬,佘志刚等.一株红树林真菌Fusarium sp. R5固相发酵代谢产物[J].中山大学学报(自然科学版),2021,60(05):136-140. DOI： 10.13471/j.cnki.acta.snus.2020C020.

DING Weijia,YE Juntao,SHE Zhigang,et al.Metabolites of a mangrove fungus Fusarium sp. R5 under solid phase fermentation[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(05):136-140. DOI： 10.13471/j.cnki.acta.snus.2020C020.

摘要

研究半红树植物苦槛蓝内生真菌

Fusarium

sp. R5固相大米培养基发酵条件代谢产物，用层析技术从乙醇提取物中纯化单体，波谱技术鉴定结构，二倍稀释法测试抗菌活性。分离到ZSU-H85 A（

），7-乙酰基-1，3，6-三羟基蒽醌 (

)

6- [ ( 7

) -8-丙氧基-1-基］-4-甲氧基吡喃-2-酮 (

)，6-戊基-4-甲氧基吡喃-2-酮 (

)，xylapyrone C（

），simplicilopyrone（

）， 2-羟甲基-3-丙基苯酚（

），(-) -brassicadiol（

），麦角甾醇和过氧麦角甾醇共10个化合物。化合物

均为首次从

Fusarium

属分离到。化合物

对香蕉炭疽菌和番茄枯萎菌显示强抗菌活性；化合物

，

对O1，O2血清型鸡大肠杆菌显示中等抑菌活性。

Abstract

The study investigated the metabolites by solid fermentation of the endophytic fungus

Fusarium

sp. R5 from the semi-mangrove plant

Myoporum bontioides

A. Gray . The metabolites were isolated from the ethanol extract by the chromatography technology. Their structures were elucidated by spectral methods. The antifungal activities were evaluated using the dilution method. Ten compounds， ZSU-H85 A （

）， 7-acetyl-1， 3， 6-trihydroxyanthracene-9， 10- dione （

）， 6-［（7

， 8

）-8-propyloxiran-1-yl］-4-methoxy-pyran-2-one （

）， 6-pentyl-4-methoxy-pyran-2-one （

）， xylapyrone C （

）， simplicilopyrone （

6）

， 2-（Hydroxymethyl）-3-propylphenol （

7）

，（-）-brassicadiol （

）， ergosterol and ergosterol peroxide were isolated. Among them， compounds

were obtained from

Fusarium

sp. for the first time. Compound

exhibited a high inhibitory activity against

Colletotrichum musae

（Berk. And M. A. Curtis） Arx. and

Fusarium oxysporum

Schlecht. f. sp. lycopersici （Sacc.） W. C. Snyder et H. N. Hansen. Compounds

，

and

showed moderate inhibitory activities against O1 and O2 serotypes of avian pathogenic

Escherichia coli

关键词

红树内生真菌Fusarium sp.代谢产物抗菌活性

Keywords

mangrove endophytic fungusFusarium sp.metabolitesantimicrobial activity

references

BLUNT J W，COPP B R，KEYZERS R A，et al. Marine natural products ［J］. Natural Product Reports， 2017， 34： 235-294.

ZHU X，ZHOU D，LIANG F，et al. Penochalasin K， a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum Ⅶ and its effective semi-synthesis ［J］. Fitoterapia， 2017， 123： 23-28.

CHEN S，CHEN D，CAI R，et al. Cytotoxic and antibacterial preussomerins from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1 ［J］. Journal of Natural Products， 2016， 79： 2397-2402.

汪开治. 苦槛蓝的开发利用［J］. 植物杂志， 1996， 5（1）： 13.

WANG K Z. The exploitation and utilization of Myoporum bontioides ［J］. Plants， 1996， 5（1）： 13.

李显珍，李春远，吴伦秀，等. 苦槛蓝叶化学成分研究［J］. 中草药， 2011， 42（11）： 2204-2207.

LI X Z， LI C Y， WU L X， et al. Chemical constituents from leaves of Myoporum bontioides ［J］. Chinese Traditional and Herbal Drugs， 2011， 42（11）： 2204-2207.

丁唯嘉，张穗强，龚兵，等. 半红树植物苦槛蓝内生真菌的分离及抗植物病原菌活性研究［J］. 广东农业科学，2014， 41： 74-78.

DING W J，ZHANG S Q，GONG B，et al. Isolation and inhibitory activity of endophytic fungi from the semi-mangrove plant Myoporum bontioides A. Gray ［J］. Guangdong Agricultural Sciences，2014， 41： 74-78.

ZHU X，ZHONG Y，XIE Z，et al. Fusarihexins A and B： novel cyclic hexadepsipeptides from the mangrove endophytic fungus Fusarium sp. R5 with antifungal activities ［J］. Planta Medica，2018， 84： 1355-1362.

王军，马文哲，汪夕芳，等. 来自海南红树林内生真菌ZSU-H85（ L. K）的新蒽醌［J］.中山大学学报（自然科学版），2010，49 （4）： 150-152.

WANG J，MA W Z，WANG X F，et al. A new anthraquinone from mangrove entophytic fungus ZSU-H85 （L. K） from Hainan Province ［J］. Acta　Scientiarum Naturalium Universitatis Sunyatseni， 2010，49 （4）： 150-152.

ZHAO D L，WANG D，TIAN X Y，et al. Anti-phytopathogenic and cytotoxic activities of crude extracts and secondary metabolites of marine-derived fungi ［J］. Marine Drugs， 2018， 16： 36.

PANG X，LIN X，TIAN Y，et al. Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004 ［J］. Natural Product Research， 2018， 32 （1）： 105-111.

YANG X L，HUANG L，LI H Y，et al. Two new compounds from the plant endophytic fungus Pestalotiopsis versicolor ［J］. Journal of Asian Natural Products Research， 2014， 17 （4）： 333-337.

EVIDENTE A，ZONNO M C，ANDOLFI A，et al. Phytotoxic α-pyrones produced by Pestalotiopsis guepinii， the causal agent of hazelnut twig blight ［J］. Journal of Antibiotics， 2012， 65： 203-206.

ZHANG H，DENG Z，GUO Z，et al. Effect of culture conditions on metabolite production of Xylaria sp. ［J］. Molecules， 2015， 20： 7940-7950.

SAETANG P，RUKACHAISIRIKUL V，PHONGPAICHIT S，et al. Depsidones and an α -pyrone derivative from Simpilcillium sp. PSU-H41， an endophytic fungus from Hevea brasiliensis leaf ［J］. Phytochemistry， 2017， 143： 115-123.

WEBER D，GORZALCZANY S，MARTINO V，et al. Metabolites from endophytes of the medicinal plant Erythrina cristagalli ［J］. Zeitschrift fur Naturforschung Section C：A Journal of Biosciences， 2005， 60： 467-477.

KURAMOCHI K，TSUBAKI K. Synthesis and structural characterization of natural benzofuranoids ［J］. Journal of Natural Products， 2015， 78（5）： 1056-1066.

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Related Author

Weijia DING

Juntao YE

Zhigang SHE

Aiqing ZHONG

Ziyang LI

Longsheng LIN

Yahong XIONG

Chunyuan LI

Related Institution

College of Materials and Energy， South China Agricultural University / Key Laboratory for Biobased Materials and Energy of Ministry of Education

School of Chemistry and Pharmacy， Guangxi Normal University

Institute of Marine Drugs / College of Pharmacy， Guangxi University of Chinese Medicine

Guangxi Zhuang Yao Medicine Center of Engineering and Technology

School of Life Sciences， Sun Yat-sen University

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Metabolites of a mangrove fungus Fusarium sp. R5 under solid phase fermentation

DOI：10.13471/j.cnki.acta.snus.2020C020

摘要

Abstract

关键词

Keywords

references