Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus <italic style="font-style: italic">Aspergillus</italic> sp.EGF15-0-3

LI Yongyi; CAI Jinxuan; FANG Yue; LI Jiaxin; ZHONG Xiaoqian; WEI Xia; LIU Bingxin; ZHANG Cuixian

doi:10.13471/j.cnki.acta.snus.2020C015

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Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3

Research articles | 更新时间：2023-11-01

- Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 61, Issue 4, Pages: 70-78(2022)
- 作者机构：
  
  广州中医药大学中药学院，广东广州510006
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2020C015
  CLC： R931.77;O629.7
- Published：25 July 2022，
  
  Published Online：14 July 2021，
  
  Received：20 July 2020，
  
  Accepted：28 October 2020
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黎咏怡,蔡金旋,方越等.南海软珊瑚共附生真菌Aspergillus sp.EGF15-0-3中色酮、蒽醌及其二聚体类化合物[J].中山大学学报(自然科学版),2022,61(04):70-78.

LI Yongyi,CAI Jinxuan,FANG Yue,et al.Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(04):70-78.
黎咏怡,蔡金旋,方越等.南海软珊瑚共附生真菌Aspergillus sp.EGF15-0-3中色酮、蒽醌及其二聚体类化合物[J].中山大学学报(自然科学版),2022,61(04):70-78. DOI： 10.13471/j.cnki.acta.snus.2020C015.

LI Yongyi,CAI Jinxuan,FANG Yue,et al.Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2022,61(04):70-78. DOI： 10.13471/j.cnki.acta.snus.2020C015.

摘要

在持续挖掘南海软珊瑚共附生真菌

Aspergillus

sp. EGF15-0-3结构新颖化合物的过程中，经多种柱色谱技术从其PDA培养基的乙酸乙酯部位分离得到9个色酮、蒽醌及其二聚体类化合物，通过波谱学方法：NMR、MS和ORD等并结合文献数据比对鉴定其结构分别为：eurorubrin （

）、anhydro flavomannin-quinone-6，6′-dimethyl ether （

）、asperflavin （

）、8-

-methyl ether-asperflavin （

）、emodin （

）、1-

-methyl emodin （

）、physcion （

）、rubrocristin （

）和3-

-（

-ribofuranosyl）-questin （

）。其中

由两分子

通过亚甲基桥链接而成，而

则是由torosachrysone与大黄素组成的杂合二聚体类化合物。化合物

为首次得到的天然产物，化合物

、

2、4

和

皆首次从

Aspergillus

属得到。

Abstract

In order to research the novel compounds from the soft coral-associated symbiotic and epiphytic fungus

Aspergillus

sp.EGF15-0-3， the column chroma tography with SiO

， ODS， Sephdex LH-20， RP-HPLC， and etc. were carried out， and two xanthones， five anthraquinones and two dimers were isolated from PDA medium. According to the （HR）ESI-MS， 1D and 2D NMR， ORD， UV， and comparison with the literatures， their structures were determined as eurorubrin （

）， anhydro flavomannin-quinone-6，6′-dimethyl ether （

）， asperflavin （

）， 8-

-methyl ether-asperflavin （

）， emodin （

）， 1-

-methyl emodin （

）， physcion （

）， rubrocristin （

）， and 3-

-（

-ribofuranosyl）-questin （

）.

consisted of two asperflavins， and

was a heterodimer of torosachrysone and emodin， and was a firstly natural product.

，

and

were obtained from genus of

Aspergillus

for the first time.

关键词

Aspergillus sp.EGF15-0-3色酮蒽醌（杂合）二聚体

Keywords

Aspergillus sp.EGF15-0-3xanthonesanthraquinonedimers

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

Zhongshan School of Medicine, Sun Yatsen University

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Xanthones， anthraquinone and their dimers from soft coral-associated symbiotic and epiphytic fungus Aspergillus sp.EGF15-0-3

DOI：10.13471/j.cnki.acta.snus.2020C015

摘要

Abstract

关键词

Keywords

references