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Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 60, Issue 3, Pages: 12-18(2021)
- 作者机构：
广东省中药上市后质量与药效再评价工程技术研究中心/广东省热带亚热带植物资源重点实验室/中山大学生命科学学院，广东 广州 510275
- 作者简介：
- 基金信息：
DOI：10.13471/j.cnki.acta.snus.2020.08.05.2020E033
CLC： R285Published：25 May 2021，
Published Online：15 April 2021，
Received：05 August 2020，
Accepted：28 October 2020
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严曾豪,张伟健,吴灏等.脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展[J].中山大学学报(自然科学版),2021,60(03):12-18.
YAN Zenghao,ZHANG Weijian,WU Hao,et al.Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(03):12-18.
严曾豪,张伟健,吴灏等.脑心通胶囊的物质基础及其改善代谢紊乱相关疾病作用及机制的研究进展[J].中山大学学报(自然科学版),2021,60(03):12-18. DOI： 10.13471/j.cnki.acta.snus.2020.08.05.2020E033.
YAN Zenghao,ZHANG Weijian,WU Hao,et al.Progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance-related diseases[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2021,60(03):12-18. DOI： 10.13471/j.cnki.acta.snus.2020.08.05.2020E033.
摘要
脑心通胶囊是由黄芪、丹参等十六味中药组成的复方中药大品种，具有益气活血、化瘀通络的功效。临床上主要用于治疗心脑血管疾病，疗效确切。大量临床研究和基础研究均表明，脑心通胶囊具有抗血小板聚集、抗血栓、抗炎、抗动脉粥样硬化、改善代谢紊乱等广泛的药效作用。代谢紊乱是大部分心脑血管疾病的共同病理基础和危险因素，本文就脑心通胶囊物质基础及改善代谢紊乱相关疾病方面的研究进展进行综述，为其揭示科学内涵以及拓展临床应用提供新思路。
Abstract
Naoxintong Capsule is a traditional Chinese medicine formulation composed of 16 traditional Chinese medicines， such as
Astragali Radix
（Huangqi） and
Salviae miltiorrhizae
Radix
et
Rhizoma
（Danshen）. It is clinically used to treat cardiovascular and cerebrovascular diseases with the functions of benefiting qi for activating blood circulation and promoting blood circulation for removing obstruction in collaterals. A number of clinical and basic studies have shown that Naoxintong Capsule possesses extensive pharmacological activities， such as anti-platelet aggregation， anti-thrombus， anti-inflammation， anti-atherosclerosis and improving metabolic disturbance. Metabolic disturbance is a common risk factor and causes most of cardiovascular and cerebrovascular diseases. This article reviewed the progress in the material basis， and effects and mechanisms of Naoxintong Capsule on metabolic disturbance and its related diseases， and proposed perspectives for its scientific intension and clinical application.
关键词
脑心通胶囊物质基础代谢紊乱心脑血管疾病作用机制
Keywords
Naoxintong Capsulematerial basismetabolic disturbancecardiovascular and cerebrovascular diseaseseffects and mechanisms
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