Pyrone metabolites of a mangrove endophytic fungus <italic style="font-style: italic">Aspergillus fumigatus </italic>SAS10 isolated from Dongzhai Harbor, Hainan

GUO Siyu; ZOU Tingguang; ZHU Jinglin; LIN Huimei; XU Wanyi; HUANG Hongbo; TAO Yiwen

doi:10.13471/j.cnki.acta.snus.2020.01.09.2020E001

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Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan

Research articles | 更新时间：2023-11-01

- Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan
- Acta Scientiarum Naturalium Universitatis Sunyatseni Vol. 59, Issue 4, Pages: 19-23(2020)
- 作者机构：
  
  广州医科大学药学院分子靶标和临床药理重点实验室/ 广州医科大学附属第五医院，广东广州 511436
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2020.01.09.2020E001
  CLC： O621.2
- Published：20 July 2020，
  
  Received：09 January 2020，
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郭思雨,邹庭光,朱静琳等.海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物[J].中山大学学报(自然科学版),2020,59(04):19-23.

GUO Siyu,ZOU Tingguang,ZHU Jinglin,et al.Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2020,59(04):19-23.
郭思雨,邹庭光,朱静琳等.海南东寨港红树林内生真菌Aspergillus fumigatus SAS10吡喃酮类代谢产物[J].中山大学学报(自然科学版),2020,59(04):19-23. DOI： 10.13471/j.cnki.acta.snus.2020.01.09.2020E001.

GUO Siyu,ZOU Tingguang,ZHU Jinglin,et al.Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2020,59(04):19-23. DOI： 10.13471/j.cnki.acta.snus.2020.01.09.2020E001.

摘要

采用大米培养基，对无瓣海桑内生真菌

Aspergillus fumigatus

SAS10进行静置发酵，运用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、以及半制备高效液相等分离手段对发酵产物进行分离纯化，获得7个化合物。经分析质谱、核磁等波谱数据，并通过与文献对比鉴定化合物为：aspergyllone（

），（

）-2-（羟基（苯基）甲基）-4H-吡喃-4-酮（

），carbonarone A（

）， campyrone A（

），campyrone C（

），asperfurandione A（

）和 dibutylterephthalate（

）。所得7个化合物均为首次报道为烟曲霉次级代谢产物。

Abstract

The mangrove endophytic fungus

Aspergillus fumigatus

SAS10 from

Sonneratia apetala

of Dongzhai haror in Hainan was fermented by using rice medium. The extract of fermentation culture was subjected to column chromatography on silica gel

column chromatography on Sephadex LH-20

and semi-preparative HPLC. Seven compounds were obtained.By analyzing mass and NMR spectroscopic data

their structures were identified as aspergyllone (

)

(

)-2-(hydroxy(phenyl)methyl)-4H-pyran-4-one (

)

carbonarone A (

)

campyrone A (

)

campyrone C (

)

asperfurandione A (

) and dibutylterephthalate (

)

respectively. All of compounds obtained are reported firstly from secondary metabolites of the mangrove endophytic fungus

Aspergillus fumigatus

关键词

红树林内生真菌Aspergillus fumigatus次级代谢产物吡喃酮类化合物

Keywords

mangroveendophytic fungusAspergillus fumigatussecondary metabolitespyrone

references

黄敬瑜, 张楚军, 姚瑜龙等. 植物内生菌生物抗菌活性物质研究进展[J]. 生物工程学报, 2017，33(2): 178 - 186.

HUANG J Y, ZHANG C J, YAO Y L, et al. Progress in antimicrobial substances of endophytes[J]. Chinese Journal of Biotechnology,2017, 33(2): 178 - 186.

CUI J L, GUO T T, REN Z X, et al. Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R.sachalinensis[J]. Public Library of Science, 2014, 10(3): e0118204.

邓祖军, 曹理想, 周世宁,等. 红树林内生真菌的分离及代谢产物生物活性的初步研究[J]. 中山大学学报(自然科学版),2010, 49(2): 100 - 104.

DENG Z J, CAO L X, ZHOU S N, et al. Isolation and metabolite bioactivities of mangrove fungal endophytes[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni , 2010, 49(2): 100 - 104.

XU Z Y, WU X, LI G, et al. Pestalotiopisorin B, a new isocoumarinderivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101[J]. Natural Product Research, 2019: 1 - 6.

李冬艳, 王晶, 陈科良,等. 来源于印度洋深海区的烟曲霉次生代谢产物的研究[J]. 海洋科学, 2019, 43(8): 43 - 49.

LI D Y, WANG J, CHEN K L, et al. Study of the secondary metabolites of Aspergillus fumigatus from the deepsea zone of the Indian Ocean[J]. Marine Sciences, 2019, 43(8): 43 - 49.

PAULUSSEN C, HALLSWORTH J E, NIERMAN W C, et al. Ecology of aspergillosis: Insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species[J]. Microb Biotechnol, 2017, 10(1): 296–322.

JENS C, CHRISTIAN R, KRISTIAN F. Metabolomics of Aspergillus fumigatus[J]. Medical Mycology, 2009, 47(1): 53 - 71.

陈彦君, 祝丽君, 于红梅,等. 一株烟曲霉抗植物病原菌活性次生代谢产物的研究[J]. 中草药, 2019, 50(22): 5400 –5404.

CHEN Y J, ZHU L J, YU H M,et al. A new alkaloid from endophytic fungus Aspergillus fumigatus of Euphorbia royleana[J]. Chinese Traditional and Herbal Drugs, 2019, 50(22): 5400-5404.

郑旭, 李慧慧, 李琦,等. 几种天然吡喃酮衍生物的抗肿瘤活性分析[J]. 浙江理工大学学报(自然科学版) 2016, 35(1), 100-102.

ZHENG X, LI H H, LI Q, et al.Anti-tumor activity anaysis of several natural pyrones derivatives[J]. Journal of Zhejiang Sci-Tech Universitaty (Natural Sciences), 2016, 35(1): 100-102.

BREUER N, GRUBER I, JANIAK C, et al. Emission solvatochromic, solid-state and aggregation-induced emissive alpha-pyrones and emission-tuneable 1H-pyridines by michael addition-cyclocondensation sequences[J]. Beilstein Journal of Organic Chemistry, 2019, 15: 2684 - 2703.

PAN L, YANG L, HUANG Y, et al. Combinatorial enzymatic synthesis of unnatural long-chain beta-branch pyrones by a highly promiscuous enzyme[J]. ACS Omega, 2019, 4 (25): 21078 - 21082.

TAN C Y, WANG F, ANAYA-EUGENIO G D, et al. Alpha-pyrone and sterol constituents of penicillium aurantiacobrunneum, a fungal associate of the lichen niebla homalea[J]. Journal Natural Product, 2017, 82(9): 2529 - 2536.

PADHI S, MASI M, SUJOGYA K, et al. Antimicrobial secondary metabolites of an endolichenic Aspergillus niger isolated from lichen thallus of Parmotrema ravum[J]. Natural Product Research, 2019: 1-8.

XU K, GUO C, SHI D, et al. Discovery of natural dimeric naphthopyrones as potential cytotoxic agents through ROS-mediated apoptotic pathway[J]. Marine Drugs, 2019, 17(4): e207.

ZHANG Y, ZHU T, FANG Y, et al. Carbonarones A and B, new bioactive g-Pyrone and a-Pyridone derivatives from the marine-derived fungus Aspergillus carbonarius[J]. The Journal of Antibiotics, 2007, 60(2): 153 - 157.

FERDINAND M T, MICHEL D K T, BIRGER D, et al. Structures and absolute configuration of threea-pyrones from an endophytic fungus Aspergillus niger[J]. Tetrahedron. 69: 7147-7151.

DING L, XU P, LI T, et al. Asperfurandiones A and B, two antifungal furandione analogs from a marine-derived fungus Aspergillus versicolor[J]. Natural Product Research, 2019, 33(23): 3404 - 3408.

张晓琦, 杨婷婷, 李国强,等. 川山橙枝叶的化学成分研究[J]. 中国中药杂志, 2013, 38(10): 178 -186.

ZHANG J, YANG T T, LI G Q, et al. Chemical constituents from twigs and leaves of Melodinus hemsleyanus[J]. China Journal of Chinese Materia Medica, 2013, 38(10): 178 -186.

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Pyrone metabolites of a mangrove endophytic fungus Aspergillus fumigatus SAS10 isolated from Dongzhai Harbor, Hainan

DOI：10.13471/j.cnki.acta.snus.2020.01.09.2020E001

摘要

Abstract

关键词

Keywords

references