The metabolites by solid fermentation of the symbiotic fungus

Fusarium

sp. ZMT01 from the intestinal tract of

Oxya chinensis

Thunber were studied. The molecules were isolated from the ethanol extract by the modern chromatography technology. Their structures were elucidated by spectral methods. The antifungal activities were evaluated using the dilution method. Eight compounds were isolated

they are

 are

3-phenylcyclopent-2-en-1-one(

1

)

2-hydroxy-3-phenylcyclopent-2-en-1-one(

2

)

kojic acid(

3

)

kojic acid monomethyl ether(

4

)

(S)-5-hydroxy-2

6-dimethyl-4H-furo[3

4-g]benzopyran-4

8 (6H)-dione(

5

)

7

8-dimethylbenzo [g] pteridine-2

4(1H

3H)-dione(

6

)

(9Z

11E)-8

13-di-hydroxyoctadeca-9

11-dienoicacid.(

7

)andstigma 7

22-dien-3β

5α

6α-triol(

8

). Among them

compounds

1

and

2

were first isolated as natural products. The

1

H NMR and

13

C NMR data of compound

2

were also reported firstly. Compounds 5-7 were obtained from

Fusarium

sp. for the first time. Compound 5 exhibited high inhibitory activities against

Fusarium graminearum

Schw. and Colletotrichum

gloeosporioides

Penz..