The study reported a novel drug delivery system

red blood cell membranes biomimetic nanoparticles (RBCM-NP) drug delivery system. The system was constructed by combining the excellent drug-carrying properties of nanoparticles and cell membranes as shells to encapsulate the synthesized nanoparticle which makes it disguise as an endogenous substance to reduce uptake of reticuloendothelial system and immune recognition. Nanoparticles (NP) were prepared by reverse solvent method

while red blood cell membranes (RBCM) were extracted by centrifugal extraction. Different ratios of RBCM and NP were co-extruded for different times to prepare RBCM-NP. RBCM-NP were characterized by transmission electron microscopy and Malvern particle size meter. The aggregation reaction of biotinylated nanoparticle (BTNP) and streptavidin (ST) were used to study the coverage of red blood cell membranes. The particle sizes of NP and RBCM-NP were uniformed. In optimized formulation

RBCM could completely encapsulate NP with good reproducibility.