Secondary metabolites from the marine actinomycete Streptomyces novaecaesareae

YU Xin; WEI Xia; FENG Chan; FAN Qian; WANG Siyu; ZHANG Weimin; ZHANG Cuixian

doi:10.13471/j.cnki.acta.snus.2019.03.008

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Secondary metabolites from the marine actinomycete Streptomyces novaecaesareae

更新时间：2023-12-11

- Secondary metabolites from the marine actinomycete Streptomyces novaecaesareae
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 58, Issue 3, Pages: 63-70(2019)
- 作者机构：
  
  1. 广州中医药大学中药学院,广东,广州,510006
  2. 
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2019.03.008
  CLC：
- Published：2019，
  
  Published Online：25 May 2019，
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YU Xin, WEI Xia, FENG Chan, et al. Secondary metabolites from the marine actinomycete Streptomyces novaecaesareae. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 58(3):63-70(2019)
DOI：

YU Xin, WEI Xia, FENG Chan, et al. Secondary metabolites from the marine actinomycete Streptomyces novaecaesareae. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 58(3):63-70(2019) DOI： 10.13471/j.cnki.acta.snus.2019.03.008.

摘要

对南海来源链霉菌

Streptomyces novaecaesareae

的次级代谢产物进行研究，经多种柱色谱技术分离得到10个化合物，通过波谱学方法并结合文献数据比对鉴定其结构分别为：环（4-羟基-

-脯

-D-

苯丙）二肽（

）、环（4-羟基-

-脯

-L-

苯丙）二肽（

）、环（（4-羟基-

-脯

-D-

脯）二肽（

）、环(（4-羟基-

-脯

-L-

亮)二肽（

）、环（

-脯

-L-

苯丙）二肽（

）、环（

-亮-

-脯）二肽（

）、环（

-脯

-L

-亮）二肽（

）、环(8-羟基-

-脯

-D-

异亮)二肽（

）、N-(4-氧代戊基)-乙酰胺(

）和邻苯二甲酸二丁酯（

）。化合物1-9为叶立德类化合物，且

1、3

和

含有自然界中不常见的

构型氨基酸。所有化合物均首次从

Streptomyces novaecaesareae

中分离得。

Abstract

By using various sorts of column chromatography

ten compounds were isolated from

Streptomyces novaecaesareae

which was isolated from the South China Sea. Based on the spectrum of NMR

MS and comparing the data with references

their structures were identified as cyclo-(

L-

4-Hypro-

D-

phe) (1)

cyclo-(4-hydroxy-

-pro-

-phe) (

)

cyclo (

Pro-

D-

trans-Hyp) (

)

cyclo (4-hydroxy-

pro-

-leu) (

)

cyclo- (-

Pro-

Phe) (

)

cyclo-(-

leu-

pro) (

)

cyclo (-

D-

Pro-

Leu) (

)

callyspongidipeptide A (

)

N-(4-oxopentyl)-acetamide (

) and dibutylphthalate (

). Compounds1-9 were Ylide compounds which were composed of naturally rare -

-configured amino acids. All Compounds were isolated from -S.

novaecaesareae

- for the first time.

关键词

Streptomyces novaecaesareae叶立德类化合物D构型氨基酸

Keywords

Streptomyces novaecaesareaeYlide compoundsD-amino acid

references

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