Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea

LI Xiuting; LIU Bingxin; HU Guping; WANG Yumei; ZHANG Cuixian

doi:10.13471/j.cnki.acta.snus.2016.01.017

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Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea

更新时间：2023-12-11

- Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 55, Issue 1, Pages: 96-101(2016)
- 作者机构：
  
  1. 广州中医药大学中药学院,广东,广州,510006
  2. 
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2016.01.017
  CLC：
- Published：2016，
  
  Published Online：25 January 2016，
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LI Xiuting, LIU Bingxin, HU Guping, et al. Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(1):96-101(2016)
DOI：

LI Xiuting, LIU Bingxin, HU Guping, et al. Anthraquinones and nitrogen secondary metabolites from the coral-derived symbiotic fungi NG-15-3 of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(1):96-101(2016) DOI： 10.13471/j.cnki.acta.snus.2016.01.017.

摘要

为了研究南海珊瑚共附生真菌NG-15-3次生代谢产物，采用硅胶柱层析和HPLC等分离手段从乙酸乙酯提取部位分离得到单体化合物，结合现代波谱技术、物理常数对照对单体化合物的结构进行结构鉴定。从其分离得到4个蒽醌类：emodin (2)〖STBZ〗、1-O-methyl emodin(3)、physcion (4)、carviolin (5)和6个含氮类次生代谢产物：preechinulin (1)、cyclo-(Phe-Gly) (6)、cyclo-(Gly-Pro)(7)、3Himidazole-4-carboxylic acid (8)、2-methyl-3H-imidazole-4-carboxylic acid (9)和1H-pyrrole-2-carboxylic acid (10)。所有化合物均为首次从该真菌中分离得到，且化合物〖STHZ〗1〖STBZ〗为单去氢2

5-二酮哌嗪类化合物的前体物质，具有丰富的生理活性。

Abstract

In order to study the secondary metabolites from the coralderived symbiotic fungi NG15-3 of South China Sea

the compounds were isolated by silica gel column chromatography and HPLC. Their structures were identified on the basis of spectral data and physical constant comparison. Four anthraquinones and six nitrogen compounds were isolated as preechinulin (1)

emodin (2)

1-O-methyl emodin(3)

physcion (4)

carviolin (5)

cyclo-(Phe-Gly) (6)

cyclo-(Gly-Pro) (7)

3H-imidazole-4-carboxylic acid (8)

2-methyl-3H-imidazole-4-carboxylic acid (9) and 1H-pyrrole-2-carboxylic acid (10). All the secondary metabolites were firstly acquired from the coralderived symbiotic fungi NG-15-3 of South China Sea and compound 1 was a precursors of the monodehydro-2

5diketopiperazines

which showed varied biological activity.

关键词

珊瑚共附生真菌NG-15-3蒽醌含氮类化合物结构鉴定

Keywords

coral-derived symbiotic fungiNG-15-3anthraquinonesnitrogen compoundsstructural identification

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Related Institution

School of Chinese Material Medica, Guangzhou University of Chinese Medicine

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