Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats

WANG Yonggang; TAN Pei; LI Peibo; XU Bing; SU Weiwei; CHEN Zhouquan; PENG Wei

doi:10.13471/j.cnki.acta.snus.2016.01.002

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Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats

更新时间：2023-12-11

- Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 55, Issue 1, Pages: 12-15(2016)
- 作者机构：
  
  1. 中山大学生命科学学院∥广州现代中药质量研究开发中心∥广东省热带亚热带植物资源重点实验室，广东,广州,510275
  2. 
- 作者简介：
- 基金信息：
- DOI：10.13471/j.cnki.acta.snus.2016.01.002
  CLC：
- Published：2016，
  
  Published Online：25 January 2016，
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WANG Yonggang, TAN Pei, LI Peibo, et al. Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(1):12-15(2016)
DOI：

WANG Yonggang, TAN Pei, LI Peibo, et al. Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(1):12-15(2016) DOI： 10.13471/j.cnki.acta.snus.2016.01.002.

摘要

采用胆总管结扎法制备肝纤维化大鼠模型，对田基黄总黄酮抗大鼠肝纤维化作用进行了研究。从造模首日起，灌胃给药，每天给予田基黄总黄酮(9、18、36 mg/kg) 1次，4周后，测定血清总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、谷草转氨酶（AST）、透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、TNF-α水平及肝组织中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSHPx）活性、丙二醛（MDA）、羟脯氨酸（Hyp）的含量及MMP-1、TIMP-1蛋白的表达。结果表明，田基黄总黄酮能显著降低胆总管结扎诱导的肝纤维化大鼠血清中TBIL、DBIL、ALT、AST、PCⅢ、HA、LN的水平、肝组织中Hyp的含量和TIMP-1蛋白的表达，说明田基黄总黄酮具有良好的抗胆汁性肝纤维化的作用。此外，田基黄总黄酮也能提高肝组织SOD、GSH-Px的活性，降低肝组织MDA及血清中TNF-α的含量。田基黄总黄酮可抑制胆总管结扎诱导的大鼠肝纤维化的形成，其抗肝纤维化作用可能与其抗氧化作用及抗TNF-α的分泌有关。

Abstract

The purpose of this study was to investigate the therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats. Liver fibrosis model was established by bile duct ligation. After bile duct ligation

the treatment groups orally received total flavonoids of Hypericum japonicum(9

36 mg·kg

-1

·d

-1

) daily for 4 weeks. Then

rats were all executed. Serum and liver tissues were obtained. Serum levels of TBIL

DBIL

ALT

AST

PCⅢ

TNF-α and the activities of SOD

GSH-Px and the contents of MDA

Hyp

MMP-1 and TIMP-1 in liver tissues were detected. Results showed that total flavonoids of Hypericum japonicum could significantly alleviate liver fibrosis

as indicated by decreasing levels of TBIL

DBIL

ALT

AST

PCⅢ

TNF-α

Hyp and TIMP-1. Moreover

total flavonoids of Hypericum japonicum could effectively enhance the activities of SOD

GSH-Px and decrease the content of MDA. Our results show that total flavonoids of Hypericum japonicum is effective in attenuating liver fibrosis induced by bile duct ligation in rats

at least partly

via enhancing the activation of antioxidant enzymes and inhibiting release of TNF-α.

关键词

田基黄总黄酮肝纤维化胆总管结扎

Keywords

total flavonoids of Hypericum japonicumliver fibrosisbile duct ligation

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