Based on the Support Vector Machine algorithm

the proteinprotein interactions (PPI) networks between Par-4

the cancerrelated apoptosis protein

and related proteins have been built. There are 82 proteins have been predicted interacting with Par-4. The proteins are classified into eight groups by biological functions

which include protein kinase

death receptor associate factor

ubiquitinprotein ligase

special disease associate proteins

DNA replication related proteins

special structure associate protein

regulatory protein and others. Combined with literatures mining and molecular chaperones of Par-4 searching from BOND database

two new signal transduction pathways of Par-4 have been deduced. In this paper

we first discover that Par-4 interacts with a group of ubiquitinproteins. We find that Par-4 has complicated interactions with many proteins. Par-4 plays a major role in some apoptosis pathways.