The silver nanoparticlesbased hydrogels were investigated in order to increase the antibacterial property in this work. The silver nanoparticles were synthesized in aqueous silver nitrate solution by adding sodium borohydride as a reduction reagent and polyvinyl pyrrolidone as a dispersion aid. And then the silver nanoparticlesbased hydrogels were further prepared in the carbomer solution by adding the dispersion solutions of silver nanoparticles with different volumes and sodium hydroxide solution. The result of UVvis analysis indicated that the silver nanoparticles were successfully synthesized. The existence of silver nanoparticles in the hydrogels was confirmed by Xray scattering analysis

and the diameters of silver nanoparticles were calculated to be about 5 nm according to the Scherrer equation. The swelling ratio of the hydrogels was determined to be 900%. The hydrogels exhibited strong antibacterial properties to

Escherichia coli

and

Staphylococcus aureus

with the content of silver nanoparticles 10 μg/mL

which is lower than the safe content of silver nanoparticles 25 μg/mL. The hydrogels are thus anticipated to be used for the treatment of wounded skin and skin disease.