Single nucleotide polymorphisms (SNPs) in multiple drug resistance 1 (MDR1) gene are associated with disease susceptibility

drug response and clinical outcome such as survival and recurrence. We conducted a systemic screen for sequence variations in all exons and part of promoter region of MDR1 gene by PCRRFLP and PCRSSCP in the Han population from Southern China. Genotype distribution differences among different ethnicity were tested by chisquare test. Five different SNPs were detected. They are T-2410C，T-129C，C1236T，G2677T/A and C3435T. The frequency of -2410C allele is 4.65%

-129C allele is 3.11%，1236T allele is 63.31%

2677T allele is 44.66%

2677A allele is 14.47%

3435T allele is 41.18%. Dramatic difference was observed in the allele distribution among different ethic populations. MDR1–2410T/C was excluded for its rare reporting. These data may be used as a basis for studies on the relationship between 〖WTBX〗MDR1〖WTBZ〗 genotypes and drug efficacy

drug toxicity

disease susceptibility in Southern China Han populations.