Two trails were conducted to investigate the effects of interaction of protein and energy levels and that of protein and vitamin B6 on growth and enzyme of protein metabolism of snakehead

Channa argus

（initial body weight (10.92±0.42)g）. Results of trail 1 indicated that weight gain of the fish increased with the increase of dietary protein level at same dietary energy level

protease specific activity in determined organs also did (P

<

0.05).Weight gain of the fish increased with the increase of energy from 14.5 MJ/kg to 16.0 MJ/kg

and then declined with the continuous increase of energy level up to 17.5 MJ/kg at same dietary protein level.Dietary protein and energy level significantly influenced glutamatepyruvate transaminase (GPT) activity in liver (P

<

0.01).Protease specific activity in determined organs was positively relatated with the increasing dietary protein level at the same dietary energy level. Dietary energy level significantly influenced protease specific activity in stomach and liver (P

<

0.01). Dietary protein level significantly influenced lactatedehydrogenase(LDH) activity in liver and muscle (P

<

0.01)

dietary energy level significantly influenced glutamatepyruvate transaminase (GPT) activity in liver (P

<

0.01) moreover significantly influenced lactatedehydrogenase (LDH) activity in liver (P

<

0.05) and LDH

GPT activity in the muscle of snakehead.Dietary energy level significantly influenced lactatedehydrogenase (LDH) activity in liver and LDH and GPT in muscle (P

<

0.01). Dietary protein to energy ratio had significant effect on GPT activity in liver (P

<

0.01). Results of trail 2 indicated that dietary protein levels had significantly improved growth performance then remained stable and significantly influenced on protease specific activity in stomach

Vitamin B6 had significantly influenced growth rate (P

<

0.05)

protease specific activity in stomach and liver (P

<

0.01).Protease specific activity in determined organs had significantly improved with the increasing dietary protein levels in same B6 level(P

<

0.05)

GPT in liver and muscle and LDH activity in muscle did (P

<

0.01)

LDH activity in liver (P

<

0.05). In the current experient

the optimal protein to energy radio was 23.3 g/MJ and feeds with adequate vitamin B6 supplementation (18~30 mg/kg) in proper protein level（34.5%~42.0%）could improve growth performance and enzyme about protein metabolism for

Channa argus

.