Spodoptera litura

nucleopolyhedrovirus (

Splt

MNPV) could not infect

Spodoptera exigua

(

Se

). To investigate the reason of abortive infection

it was detected the pathology of Se301 cells infected by

Splt

MNPV using different methods

such as microscope

electron microscope and DAPI (4′

6-Diamidine2′phenylindole dihydrochloride) staining

et al.The results demonstrated that the

Splt

MNPVinfected Se301 cells had obvious pathologic changes deduced as early apoptosis character

but these infected Se301 cells did not process to late apoptosis namely forming apoptosis bodies. There was no infectious BV and ODV in the Se301 cells infected by

Splt

MNPV all the time

suggesting that early apoptosis was still one of the limited factors in viral replication cycle.