Chemical Constituents of  Clematis chinensis Osbeck

ZHAO Yang; LIANG Lizhen; LI Houjin; WEN Shiya; LAN Wenjia

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Chemical Constituents of Clematis chinensis Osbeck

更新时间：2023-12-11

- Chemical Constituents of Clematis chinensis Osbeck
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 51, Issue 3, Pages: 63-67(2012)
- 作者机构：
  
  1. 中山大学药学院,广东,广州,510006
  2. 中山大学化学与化学工程学院,广东,广州,510275
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
  
  Published Online：25 May 2012，
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ZHAO Yang, LIANG Lizhen, LI Houjin, et al. Chemical Constituents of Clematis chinensis Osbeck. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(3):63-67(2012)
DOI：

ZHAO Yang, LIANG Lizhen, LI Houjin, et al. Chemical Constituents of Clematis chinensis Osbeck. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(3):63-67(2012) DOI：

摘要

威灵仙是一种重要的中药材。运用快速硅胶柱层析和制备型HPLC技术对威灵仙的乙酸乙酯提取物进行分离，纯化得到7个化合物，它们是松脂素（Pinoresinol

），Epipinoresinol（

），罗汉松脂素（Matairesinol

），Salicifoliol（

），3

5-三羟基苯甲酸（

），4羟基-3

5-二甲氧基苯甲酸（

），异阿魏酸（

），化合物的结构通过NMR和MS的分析得到确定。运用分析型HPLC和GCMS色谱分析方法，可以在威灵仙药材提取物中快速、准确地鉴定该类化合物。化合物

是木脂素类化合物，具有多种重要的生理活性，潜在药用明显。

Abstract

Clematis chinensis

Osbeck is a popular medicinal plant. Seven known compounds

pinoresinol (

)

epipinoresinol (

)

matairesinol (

)

salicifoliol (

)

5-trihydroxybenzoic acid (

)

4hydroxy3

5dimethoxybenzoic acid (

)

and 3hydroxy 4 methoxycinnamic acid (

) were isolated from the ethyl acetate extract of

Clematis chinensis

Osbeck by using the flash silica gel column chromatography and preparative high performance liquid chromatography. Their structures were elucidated mainly on the basis of NMR and MS data. These compounds could be fast and accurately detected from the extract by using HPLC and GCMS analytical methods. Lignans

have various bioactivities

and the lignans from

Clematis chinensis

Osbeck should have the potential application in drug development.

关键词

威灵仙木脂素松脂素化学成分活性

Keywords

Clematis chinensisOsbecklignanpinoresinolchemical constituentsbioactivity

references

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Related Institution

Key Laboratory of Modern Chinese Medicines and Department of Pharmacognosy,China Pharmaceutical University

State Key Laboratory of Phytochemistry and Plant Resources in West China,Kun ming Institute of Botany,Chinese Academy of Sciences

Key Lab of Tropical Medicinal Plant Chemistry of Hainan Province, Department of Chemistry,Hainan Normal University



Institute of Tropical Biosciences and Biotechnology, Chinese Academy ofTropical Agricultural Sciences

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