Discovery and Analysis of ProteinProtein Interaction Sites of PB1-PANuclease Complex of Influenza A Virus

HE Miao; LIN Qiangqian; ZHAO Yanchao; ZHANG Shubo; CHAN Daniel Wai Tin

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Discovery and Analysis of ProteinProtein Interaction Sites of PB1-PANuclease Complex of Influenza A Virus

更新时间：2023-12-11

- Discovery and Analysis of ProteinProtein Interaction Sites of PB1-PANuclease Complex of Influenza A Virus
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 50, Issue 2, Pages: 81-86(2011)
- 作者机构：
  
  1. 中山大学生命科学学院,广东,广州,510275
  2. 
  3. 香港理工大学屋宇设备工程系，香港九龙
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011，
  
  Published Online：25 March 2011，
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HE Miao, LIN Qiangqian, ZHAO Yanchao, et al. Discovery and Analysis of ProteinProtein Interaction Sites of PB1-PANuclease Complex of Influenza A Virus. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 50(2):81-86(2011)
DOI：

HE Miao, LIN Qiangqian, ZHAO Yanchao, et al. Discovery and Analysis of ProteinProtein Interaction Sites of PB1-PANuclease Complex of Influenza A Virus. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 50(2):81-86(2011) DOI：

摘要

基于共进化理论，探究了甲型流感病毒PB1蛋白与PA蛋白上具有共同进化可能性的保守九聚片段 (C9MP)。结构信息显示PB1蛋白的第1-15位氨基酸与PA蛋白的第239-716位氨基酸具有相互作用域；对该区域变异分布的分析发现，PA蛋白第670位氨基酸Q所在的C9MP与PB1蛋白的第9位氨基酸F、第12位氨基酸V和第13位氨基酸P所在的C9MP在PB1-MP1相互作用面上具有最低的共进化值。结合DSSP程序的分析表明，由PA蛋白第670位氨基酸Q与PB1蛋白的第9位氨基酸F、第12位氨基酸V与第13位氨基酸P构成的区域可能成为潜在的相互作用位点。

Abstract

Based on co-evolution theory

this research tries to locate the protein interaction sites in conserved 9mer peptides (C9MP) between PB1 protein and PA protein in the nuclease complex of influenza A virus. There exist interaction regions between sites 1-15 amino acids of PB1 protein and sites 239-716 amino acids of PA protein from structure message. It is revealed by variation analysis to this region that

on PB1-MP1 contact surface

there is a minimum co-evolution value between the conserved 9mer peptide where Q670 of PA protein is located and the conserved 9mer peptide where F9

V12 and P13 of PB1 protein are located. Combined with DSSP analysis results

the regions formed by four amino acids

Q670 of PA protein

V12 and P13 of PB1 protein

are potential interaction sites.

关键词

共进化理论甲型流感病毒PB1蛋白PA蛋白相互作用位点

Keywords

co-evolution theoryinfluenza A virusPB1PAinteraction site

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