HPLC fingerprint of Qutanzhike Granule was established with Elite Hypersil BDS column（4.6 mm×250 mm

5 μm）

methanol(A) and 0.15% acetic acid(B) as mobile phase.The elution profile was: 0~95 min 15% to 75% A in B(linear gradient). The column temperature was set at 25 ℃ and the flow rate was 1.0 mL/min. The detective wavelength was at 260 nm. 19 common peaks were selected as the fingerprint peaks from 12 batches of the production. In the established fingerprint

10 flavonoids were identified by the HPLC-ESI/MS/MS based on MS spetra and standard reference. The method can be used for quality control of Qutanzhike Granule with great precision

accuracy and good reproducibility.