Synthesis, Characterization, DNAbinding and Antioxidant Activity Studies of Ruthenium(Ⅱ) Complex

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Synthesis, Characterization, DNAbinding and Antioxidant Activity Studies of Ruthenium(Ⅱ) Complex

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- Synthesis, Characterization, DNAbinding and Antioxidant Activity Studies of Ruthenium(Ⅱ) Complex
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 51, Issue 1, Pages: 72-75(2012)
- 作者机构：
  
  广东药学院医药化工学院,广东,中山,528458
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
  
  Published Online：25 January 2012，
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Synthesis, Characterization, DNAbinding and Antioxidant Activity Studies of Ruthenium(Ⅱ) Complex. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(1):72-75(2012)
DOI：

Synthesis, Characterization, DNAbinding and Antioxidant Activity Studies of Ruthenium(Ⅱ) Complex. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(1):72-75(2012) DOI：

摘要

设计合成一个新的钌(Ⅱ)多吡啶配合物［Ru(dip)

(DBHIP)］(ClO

)

{dip = 4

7-二苯基-1，10-邻菲咯啉;DBHIP = 2-(3

5-二溴-4-羟基苯)并咪唑［4

4-f］-(1

10-邻菲啰啉)}，采用元素分析，质谱和1H NMR对其进行表征。用电子吸收光谱、黏度测试、Jobplot荧光滴定法研究配合物与CT DNA作用，结果表明配合物以经典的插入模式与DNA键合。采用琼脂糖凝胶电泳实验研究配合物诱导pBR322DNA断裂。同时也研究配合物在高浓度情况下使pGL3 DNA缩合。

Abstract

A novel ruthenium(Ⅱ) polypyridyl complex ［Ru(dip)

(DBHIP)］(ClO

)

(dip = 4

7- diphenyl-1

10-phenanthroline

DBHIP = 2-(3

5-dibromo-4-hydroxyphenyl)imidazo ［4

5-f］［1

10］phenanthroline) was synthesized and characterized. The DNAbinding property of the complex was investigated by spectroscopic methods and viscosity measurement. The results indicated that the complex interacted with DNA through intercalative mode. The photocleavage of pBR322 DNA by Ru(Ⅱ) complex was investigated. The complex induced the aggregation of plasmid pGL3 DNA by Gel retardation assay.The antioxidant activity of the ligand and the complex was also performed.

关键词

钌(Ⅱ)配合物DNA缩合DNA键合

Keywords

ruthenium complexDNA condensationDNAbinding

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