Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp. from the South China Sea

WEI Meiyan; LI Shangde; YUAN Ningning; LIANG Liping; SHE Zhigang; LIN Yongcheng

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Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp. from the South China Sea

更新时间：2023-12-11

- Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp. from the South China Sea
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 51, Issue 2, Pages: 59-62(2012)
- 作者机构：
  
  1. 广东医学院药学院,广东,东莞,523808
  2. 广州工程技术职业学院,广东,广州,510075
  3. 
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
  
  Published Online：25 March 2012，
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WEI Meiyan, LI Shangde, YUAN Ningning, et al. Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp. from the South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(2):59-62(2012)
DOI：

WEI Meiyan, LI Shangde, YUAN Ningning, et al. Research on the Secondary Metabolites and Their Cytotoxic Activity of Mangrove Endophytic Fungus Nigrospora sp. from the South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(2):59-62(2012) DOI：

摘要

对采自湛江红树林内生真菌

Nigrospora

sp.的次级代谢产物进行了首次研究。利用硅胶柱层析、制备薄层层析和重结晶等方法，从该菌培养液的乙酸乙酯相中分离得到3个聚酮类次级代谢产物，运用现代波谱技术鉴定其结构分别为Griseofulvin（1），Vermixocin B (2)和Tenellic acid A (1)。化合物1的立体结构还通过X射线单晶衍射进一步得以确定。体外细胞毒活性测试表明，化合物1对人口腔表皮样癌（鳞癌）细胞KB，人口腔鳞癌多药耐药细胞KBV200，和人肺腺癌细胞A549的细胞毒活性IC

分别为8.23

9.10和14.26 μmol/L。

Abstract

Research on the secondary metabolites of the mangrove endophytic fungus

Nigrospora

sp. from the South China Sea was reported. Three secondary metabolites were isolated from the ethyl acetate extract of the fermentation by silica gel column chromatography

preparative thin layer chromatography and recrystallgraphy. Their structures were identified by comprehensive spectroscopic methods as Griseofulvin (1)

Vermixocin B (2)

Tenellic acid A(3). The absolute configuration of compound 1 was further confirmed by singlecrystal X-ray analysis. The cytotoxic activity of compound 1in vitro was also evaluated

and compound 1 showed medium activity against KB，KBV200，and A549 cell lines with IC

 of 8.23

9.10 and 14.26 μmol/L

respectively.

关键词

红树林内生真菌次级代谢产物细胞毒活性单晶X-ray

Keywords

mangrove endophytic fungussecondary metabolitescytotoxic activityX-ray diffraction

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Related Institution

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School of Pharmacy, Guangdong Medical College

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