Design Synthesis and Application of Anti-tumor  Compound 6-Bromo-Indole-3-Carbinol

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Design Synthesis and Application of Anti-tumor Compound 6-Bromo-Indole-3-Carbinol

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- Design Synthesis and Application of Anti-tumor Compound 6-Bromo-Indole-3-Carbinol
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 51, Issue 2, Pages: 63-65(2012)
- 作者机构：
  
  1. 暨南大学药学院中药及天然药物研究所,广东,广州,510632
  2. 2．广东省中药药效物质基础及创新药物研究重点实验室,广东,广州,510632
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
  
  Published Online：25 March 2012，
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Design Synthesis and Application of Anti-tumor Compound 6-Bromo-Indole-3-Carbinol. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(2):63-65(2012)
DOI：

Design Synthesis and Application of Anti-tumor Compound 6-Bromo-Indole-3-Carbinol. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 51(2):63-65(2012) DOI：

摘要

以邻硝基甲苯为原料，通过溴化、类羟醛缩合、成环、甲酰化和还原等步骤合成6-溴代吲哚-3-甲醇，总收率26.5%，所有化合物的结构均经核磁共振谱（NMR）、质谱（ESI-MS）等方法确证。以标题化合物为结构框架，合成系列6-位取代的吲哚-3-甲醇衍生物，可获得类药性好的化合物。

Abstract

Applying

-nitrotoluent as starting material

6-bromo-indole-3-carbinol was synthesized via multiple-step reactions including bromidation

aldollike condensation

cyclization

Vilsmeier-Haack formylation and reduction. The overall yield reaches 26.5%. The structures of all the products have been confirmed by ESI-MS and NMR. Based on the scaffold of the title compound

series of 6-substituted indole-3-carbinols can be prepared in search for the better drug-like compounds.

关键词

吲哚-3-甲醇抗肿瘤药物合成

Keywords

indole-3-carbinolanti-tumorpharmaceutical synthesis

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