A Quantitative Method Using One Marker for Simultaneous Assay of Four Effective Components in Compound Xueshuantong Capsule

LIANG Jieping; CHEN Si; XIE Chengshi; PENG Wei; SU Weiwei

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A Quantitative Method Using One Marker for Simultaneous Assay of Four Effective Components in Compound Xueshuantong Capsule

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- A Quantitative Method Using One Marker for Simultaneous Assay of Four Effective Components in Compound Xueshuantong Capsule
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 52, Issue 5, Pages: 123-126(2013)
- 作者机构：
  
  1. ．中山大学生命科学学院,广东,广州,510275
  2.  2．广东众生药业股份有限公司,广东,东莞,523325
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
  
  Published Online：25 October 2013，
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LIANG Jieping, CHEN Si, XIE Chengshi, et al. A Quantitative Method Using One Marker for Simultaneous Assay of Four Effective Components in Compound Xueshuantong Capsule. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(5):123-126(2013)
DOI：

LIANG Jieping, CHEN Si, XIE Chengshi, et al. A Quantitative Method Using One Marker for Simultaneous Assay of Four Effective Components in Compound Xueshuantong Capsule. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(5):123-126(2013) DOI：

摘要

为建立复方血栓通胶囊中4个有效成分的一测多评定量方法，采用高效液相色谱法，以人参皂苷Rg

为参照对照品，计算其与三七皂苷R

、人参皂苷Re、人参皂苷Rb

的相对校正因子，并进行含量计算，实现一测多评；同时采用外标法验证一测多评法的准确性。实验结果显示校正因子重现性好，采用校正因子计算的含量值和外标法实测值之间没有显著性差异。故采用一测多评法同时测定复方血栓通胶囊中4个有效成分的含量，具有准确、简便、经济实用等优点，值得推广。

Abstract

The paper reported the establishment of a quantitative method for simultaneously determining four effective components in Compound Xueshuantong capsule by using one chemical reference

the new quality evaluation method

quantitative analysis of multicomponents by single marker(QAMS)

using Ginsenoside Rg

as the internal reference substance

was developed by HPLC to simultaneously determine Notoginsenoside R

Ginsenoside Rg

Ginsenoside Re

Ginsenoside Rb

in Compound Xueshuantong capsule with the relative correction factor (RCF). In addition

the results of QAMS method were validated by comparing with that of external standard method. The results show that the RCFs have good reproducibility and no significant differences between the quantitative results of QAMS method and external standard method were observed. So

it is a accurate

convenient and practical method to simultaneously determine four effective components in Compound Xueshuantong capsule for its quality control．

关键词

复方血栓通胶囊一测多评校正因子高效液相色谱法

Keywords

Compound Xueshuantong CapsuleQAMSrelative correction factorHPLC

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Related Institution

School of Life Sciences，Sun Yatsen University

Guangzhou Baiyunshan Hutchison Whampoa Traditional Chinese Medicine Co， Ltd，Guangzhou



中山大学生命科学学院

广州市花城制药厂

Postal code：510275
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