Anti-tumour Secondary Metabolites from the Coral-derived #br#
Bacteria L-4 of South China Sea

GUO Qing; WANG Jian; YAO Junhua; LEI Lingfang; CHEN Xiaojie; DENG Yun; HUANG Zhaosheng; ZHANG Cuixian

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Anti-tumour Secondary Metabolites from the Coral-derived #br# Bacteria L-4 of South China Sea

更新时间：2023-12-11

- Anti-tumour Secondary Metabolites from the Coral-derived #br# Bacteria L-4 of South China Sea
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 52, Issue 3, Pages: 77-82(2013)
- 作者机构：
  
  1. ．广州中医药大学中药学院,广东,广州,510006
  2.  2．广州中医药大学基础医学院,广东,广州,510006
  3.  3．中山大学分析测试中心,广东,广州,510275
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
  
  Published Online：25 May 2013，
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GUO Qing, WANG Jian, YAO Junhua, et al. Anti-tumour Secondary Metabolites from the Coral-derived #br# Bacteria L-4 of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(3):77-82(2013)
DOI：

GUO Qing, WANG Jian, YAO Junhua, et al. Anti-tumour Secondary Metabolites from the Coral-derived #br# Bacteria L-4 of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(3):77-82(2013) DOI：

摘要

在研究珊瑚微生物混合共培养时发现：在混合培养中南海珊瑚内生细菌L-4对真菌的次生代谢产物明显产生影响，甚至产生此二微生物单独培养时所不产生的物质。对L-4发酵液进行次生代谢产物研究，从中分离纯化得到8个单体化合物，通过现代波谱分析（MS、NMR等）和物理常数对照等手段确定其结构依次为：环（色-丙）二肽（

）、环（甘-酪）二肽（

）、环（丙-酪）二肽（

）、环（缬-酪）二肽（

）、环（甘-苯丙）二肽（

）、环（甘-脯）二肽（

）、环（丙-缬）二肽（

）、环（甘-丙）二肽（

）均为环二肽类物质，且均首次从南海珊瑚内生细菌中分离得到，对进一步研究其可能的代谢机制具有重要意义。

Abstract

The influence of secondary metabolites on the mix-cultivate marine bacteria and fungus were studied.The result indicated that bacteria obviously affected the secondary metabolites of fungus in the mix-cultivate

and even produce substances that were not found in the fungus or bacteria separately culture by TLC. Eight compounds were obtained from the fermentation broth of coral-derived bacteria L-4 in South China Sea. Their structures were determined to be cyclo (TrpAla)

(1)

cyclo (GlyTyr)(

)

cyclo (AlaTyr) (

)

and cyclo (ValTyr)(

)

cyclo (GlyPhe)(

)，cyclo (GlyPro)(

)

cyclo (AlaVal)(

)

and cyclo (GlyAla)(

) by spectroscopic analysis. The compounds

were all cyclo-dipeptides and first obtained from the marine coral-derived bacterium of South China Sea

which attributed to further research metabolism of mix-cultivation.

关键词

珊瑚细菌混合培养次级代谢产物环二肽结构鉴定

Keywords

coral derived bacteriamix-cultivatesecondary metabolitescyclo-dipeptidesstructure identification

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