Synthesis and Characterization of Multiarmed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer

ZHANG Xuan; PENG Yuefeng; CAI Qingqing

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Synthesis and Characterization of Multiarmed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer

更新时间：2023-12-11

- Synthesis and Characterization of Multiarmed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 52, Issue 3, Pages: 83-86(2013)
- 作者机构：
  
  1. 深圳市精神卫生中心,广东,深圳,518020
  2. 
  3. 深圳市心理健康重点实验室,广东,深圳,518020
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
  
  Published Online：25 May 2013，
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ZHANG Xuan, PENG Yuefeng, CAI Qingqing. Synthesis and Characterization of Multiarmed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(3):83-86(2013)
DOI：

ZHANG Xuan, PENG Yuefeng, CAI Qingqing. Synthesis and Characterization of Multiarmed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 52(3):83-86(2013) DOI：

摘要

以第二代聚丙烯亚胺树状大分子（PPI）末端的氨基为引发剂，与L-谷氨酸苄酯的〖WTBX〗N〖WTBZ〗-酸酐（BLG-NCA）进行开环聚合合成了多臂聚丙烯亚胺-聚谷氨酸苄酯聚合物，分别用IR、

H NMR、

C NMR和GPC对聚合物结构进行表征。结果表明，PPI端氨基能够作为引发剂参与反应引发BLG-NCA开环聚合，并证实成功合成了多臂聚丙烯亚胺-聚谷氨酸苄酯聚合物。该聚合物有望成为新型的非病毒基因载体材料。

Abstract

Multi-armed polypropylenimine dendrimer-poly(benzyl-L-glutamate) was synthesized by ring-opening polymerization of BLG-NCA using primary amineterminated polypropylenimine dendrimer (PPI) as the macroinitiator. Its chemical structure was characterized by IR



H NMR

C NMR

and GPC analysis. The results showed that the primary amine of PPI participated in initiating the ring-opening polymerization of BLG-NCA monomer. And multiarmed polypropylenimine dendrimer-poly(benzyl-L-glutamate) was successful synthesized. The multi-armed polymer might be a potential candidate as nonviral gene carriers.

关键词

聚丙烯亚胺树状大分子聚谷氨酸苄酯非病毒基因载体开环聚合

Keywords

polypropylenimine dendrimerpoly(benzyl-L-glutamate)nonviral gene carrierring-opening polymerization

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