Research on Cyclo-Dipeptides from the Coral-Derived Endophytic Bacteria Pelomonas puraquae sp.nov of South China Sea

DENG Yun; HU Guping; CHEN Xiaojie; LIU Bingxin; DAI Shuwen; HE Xixin; ZHANG Cuixian

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Research on Cyclo-Dipeptides from the Coral-Derived Endophytic Bacteria Pelomonas puraquae sp.nov of South China Sea

更新时间：2023-12-11

- Research on Cyclo-Dipeptides from the Coral-Derived Endophytic Bacteria Pelomonas puraquae sp.nov of South China Sea
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 54, Issue 3, Pages: 80-84(2015)
- 作者机构：
  
  1. 广州中医药大学中药学院,广东,广州,510006
  2. 
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2015，
  
  Published Online：25 June 2015，
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DENG Yun, HU Guping, CHEN Xiaojie, et al. Research on Cyclo-Dipeptides from the Coral-Derived Endophytic Bacteria Pelomonas puraquae sp.nov of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 54(3):80-84(2015)
DOI：

DENG Yun, HU Guping, CHEN Xiaojie, et al. Research on Cyclo-Dipeptides from the Coral-Derived Endophytic Bacteria Pelomonas puraquae sp.nov of South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 54(3):80-84(2015) DOI：

摘要

为了研究珊瑚内生细菌 Pelomonas puraquae sp. nov(B-2)次生代谢产物，采用现代分离纯化方法对其发酵液和菌丝体的次生代谢产物进行分离、纯化，得到8个单体化合物。通过现代波谱分析(1D NMR和MS等)和物理常数对照等方法对其进行结构鉴定，均为环二肽类物质，依次为：环（羟脯-苯丙）二肽（1）、环（脯-酪）二肽（2）、环（苯丙-甘）二肽（3）、环（苯丙-丙）二肽（4）、环（丙-酪）二肽（5）、环（亮-甘）二肽（6）、环（甘-缬）二肽（7）、环（丙-缬）二肽（8）。所有化合物均首次从该细菌中分离得到。

Abstract

Eight compounds 1-8 were obtained from the fermentation broth and mycelium of B-2 through modern methods for isolation and purification in order to research secondary metabolites from coral-derived endophytic bacteria Pelomonas puraquae sp. nov(B-2) . Their structures were analyzed by 

H and 

-C NMR

MS and physical methods. The results indicated that they were composed of 8 compounds including cyclo(Hyp-Phe)(1)

cyclo(Pro-Tyr)(2)

cyclo(Phe-Gly)(3)

cyclo(Phe-Ala)(4)

cyclo(Ala-Tyr)(5)

cyclo(Leu-Gly)(6)

cyclo(Gly-Val)(7) and cyclo(Ala-Val)(8). They were all cyclodipeptides and first acquired from the coralderived endophytic bacteria Pelomonas puraquae sp. nov(B-2).

关键词

珊瑚内生细菌Pelomonas puraquae sp. nov(B-2)次生代谢产物环二肽结构鉴定

Keywords

coral-derived endophytic bacteriaPelomonas puraquae sp. nov(B-2)secondary metabolitescyclo-dipeptidesidentification

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Related Institution

School of Pharmaceutical Sciences， Guangzhou University of Chinese Medicine

Guangdong Institute of Microbiology / State Key Laboratory of Applied Microbiology Southern China / Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application / Guangdong Open Laboratory of Applied Microbiology

．广州中医药大学中药学院

 2．广州中医药大学基础医学院

 3．中山大学分析测试中心

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