In order to investigate the protective effects of 〖WTBX〗Momordica charantia〖WTBZ〗 extract (MCE) on obesity and insulin resistance

C57BL/6j mice fed in a high-fat diet (HFD) were used as animal model. Obese mouse model was successfully made after 2-week HFD induction. The mice were then randomly divided into normal control

model control

MCE dose of 13.5

27.0

and 54.0 g/kg treated groups. Mice in normal and model control groups were treated with 0.5% CMC-Na

and other groups were treated with MCE (i.g.)

respectively

with the same volume twice a day for ten weeks. It was shown that the body weight

epididymal and total visceral white adipose tissue weight were decreased by treatment of MCE 54.0 g/kg without the change of food intake. The increased serum TG

CHO

LDL-C

glucose

insulin concentration and insulin resistance index were significantly inhibited. The concentration of TG was also decreased by the treatment of MCE 27.0 g/kg; while the concentration of HDL-C was increased by the treatment of MCE 13.5

27.0 and 54.0 g/kg

respectively The adipocyte hypertrophy induced by HFD was mitigated by MCE dosedependently.