Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS
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Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS
Acta Scientiarum Naturalium Universitatis SunYatseniVol. 53, Issue 4, Pages: 101-106(2014)
作者机构:
1. 中山大学生命科学学院,广东,广州,510275
2.
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Published:2014,
Published Online:25 July 2014,
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HUANG Xin, ZHANG Chao, ZHOU Cuilan, et al. Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 53(4):101-106(2014)
DOI:
HUANG Xin, ZHANG Chao, ZHOU Cuilan, et al. Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 53(4):101-106(2014)DOI:
Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS
Sixteen impurities in clindamycin palmitate hydrochloride dispersible tablets were identified according to their fragmentation patterns and characteristic fragment ions by UFLC-Q-TOF-MS/MS in a positive mode. Among them
clindamycin nonanoate
clindamycin decanoate
clindamycin monodecanoate
clindamycin tridecanoate were firstly detected. These results provided a basis for quality control of clindamycin palmitate hydrochloride dispersible tablets.