Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO<sub>3</sub>

HUANG Yugang; CHU Yuehuan; HE Minghui; ZENG Zhaohua; YANG Jianwen

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Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO₃

更新时间：2023-12-11

- Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO₃
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 53, Issue 3, Pages: 73-79(2014)
- 作者机构：
  
  1. 广州医科大学药学院化学教研室,广东,广州,510183
  2.  2中山大学化学与化学工程学院//聚合物复合材料及功能材料教育部重点实验室,广东,广州,510275
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014，
  
  Published Online：25 May 2014，
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HUANG Yugang, CHU Yuehuan, HE Minghui, et al. Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO₃. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 53(3):73-79(2014)
DOI：

HUANG Yugang, CHU Yuehuan, HE Minghui, et al. Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO₃. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 53(3):73-79(2014) DOI：

摘要

结合 N-羧基-环内酸酐开环聚合和“巯-炔”光点击反应制备了侧链富含羧基的多肽基双亲水杂化共聚物 (PEO-b-PPLG-g-MPA)。该多肽基共聚物可以模拟蛋白质指导CaCO

在水溶液中的形成。圆二色谱(CD)揭示了多肽链段在水溶液中的构象变化；扫描电子显微镜(SEM)揭示了矿化过程中CaCO

的形貌变化；X射线衍射(XRD)确认了CaCO

的晶型。结果表明，该聚合物可以有效地控制CaCO

的形貌，此时多肽链段呈无规线团构象，而不是更为有序的α-螺旋或β-折叠构象；多肽链段的含量只有达到足够的浓度时，才能有效地控制的CaCO

晶体的生长；CaCO

的形貌则可以通过调节多肽链段的长度、溶液的pH值等因素进行调控，其可以是表面光滑的微球、表面堆满了CaCO

小颗粒的超结构微球、纳米棒或呈“花瓣状”聚集的纳米棒。XRD则证明形成的CaCO

呈稳定的方解石晶型。

Abstract

Polypeptide-based doubly-hydrophilic hybrid copolymers (PEO-b-PPLG-g-MPA) containing a great amount of carboxyl groups at the sidechains of polypeptide blocks were synthesized by combination of ring opening polymerization of N-carboxyanhydrides (NCAs) and thiol-yne photo-click reaction. The obtained polypeptidebased doublyhydrophilic hybrid copolymers (DHHC) were used as protein template to direct biomineralization of CaCO

in aqueous solution. Conformational changes of the polypeptide blocks were revealed by circular dichroism (CD) spectroscopy. Morphology of the obtained CaCO

was investigated by scanning electron microscope (SEM). Crystal form of the CaCO

was confirmed by x-ray diffraction (XRD). The results of CD analysis indicated that the polypeptide blocks could effectively control the morphology of CaCO

in water when they adopted random coil conformation

rather than more ordered α-helix or β-sheet. SEM analysis showed that the growth of the CaCO

crystals was strongly dependent on the concentration of polypeptides. Furthermore

the morphology of CaCO

was tunable by the variation of length of polypeptide blocks and pH value of the aqueous solution. CaCO

could form the microsphere with smooth surface

spherical superstructures with some tiny disklike particles grown on the surface and “flower” aggregated nanorod structures. XRD analysis verified that the obtained CaCO

was calcite in a very stable form in nature.

关键词

羧基多肽双亲水杂化共聚物碳酸钙

Keywords

carboxyl groupspolypeptidedoubly-hydrophilic hybrid copolymerscalcium carbonate

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Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO3

DOI：

摘要

Abstract

关键词

Keywords

references

Polypeptide-Based Doubly-Hydrophilic Hybrid Copolymers Containing Carboxyl Groups for Control of the Form of CaCO₃