Consistency evaluation was processed between domestic clindamycin palmitate hydrochloride dispersible tables and the original oral solution. HPLC method was applied to detect related substances with acetate (A) and 5 mmol/L ammonium acetatesolutionacetonitrile (50:50) (B) as mobile phase eluting in gradient. Dissolution was conducted by stirring paddle method with w=0.4% SDS as dissolution medium

at the rotate speed of 75 r/min for quality comparison between two products.The results showed that the kinds and total contents of related substances in clindamycin palmitate hydrochloride dispersible tablets were lower than that of the original oral solution products and the dissolution rates of both products reached more than 94% in 20 minutes.