To improve the property of poloxamer hydrogels

temperature sensitive hydrogels were prepared from poloxamer and five kinds of polysaccharides as well as their derivatives with different chemical structures in this work. The effect of the chemical structures of polysaccharides and their derivatives on the hydrogel properties was investigated. The result indicated that the polysaccharides and their derivatives could form the hydrogels with poloxamer at the temperature (34~37 ℃) near human beings-temperature

which is advantageous for the injection application. The amphiphilic polysaccharide derivative/poloxamer hydrogels exhibited higher stabilities

stronger shear thinning behaviours

longer time for releasing hydrophobic drug of prednisone. These properties are probably related to the hydrophobic interactions between the amphiphilic polysaccharide derivatives and poloxamer. Five kinds of temperature sensitive hydrogels all exhibited the property for promoting the growth of osteoplasts

showing the potential application in the osseous junction's tissues.