A novel and sensitive method was established for the determination of Vitamin C and Paracetamol in Vitamin C Yinqiao Tablets using Capillary Electrophoresis (CE) equipped with a photo-diodearray detector. The running buffer solution was 30 mmol·L

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sodium hydrogen phosphate solution containing 30 mmol·L

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 sodium deoxycholate (pH＝8.89). The capillary column efficient length was 40 cm (i. d 75 μm) with the separation voltage ＋20 kV. The result indicated that the peak area of Paracetamol and Vitamin C had a good linear relationship with their concentrations in a certain concentration range. The recoveries of both were more than 97.6% with RSDs less than 3.2%. CE method was simple and rapid in operation

sensitive and reliable in determination results with very little sample consumption

which can be used for the determination of Paracetamol and Vitamin C in Vitamin C Yinqiao Tablets.