Stability of efficacy composition content of different thymopentins
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Stability of efficacy composition content of different thymopentins
Acta Scientiarum Naturalium Universitatis SunYatseniVol. 55, Issue 4, Pages: 87-94(2016)
作者机构:
1. 蚌埠医学院,安徽,蚌埠,233030
2. 安徽宏业药业有限公司,安徽,蚌埠,233045
3. 安徽省蚌埠市食品药品监督管理局,安徽,蚌埠,233000
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Published:2016,
Published Online:25 July 2016,
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XUE Hongbao, CHANG Hualan, LIANG Lili, et al. Stability of efficacy composition content of different thymopentins. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(4):87-94(2016)
DOI:
XUE Hongbao, CHANG Hualan, LIANG Lili, et al. Stability of efficacy composition content of different thymopentins. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 55(4):87-94(2016)DOI:
Stability of efficacy composition content of different thymopentins
Reversed phase high performance liquid chromatography was used to analyze three types of the 10 batches thymopentin preparation: water injection
powder injection and solid preparation
and their efficacy assessments were processed through composition content determination. The result indicated that the efficacy composition contents of water and powder injection drugs were higher than that of solid preparation. This could be due to water and powder injection preparation forms were sterile products. The thymopentin composition was not easy to decompose and metamorphic with single matrix components under aseptic conditions. Several factors are not conducive thymopentin solid preparation to stability: solid preparation as entericcoated troche are nonsterile products
in addition
the troche of the corresponding supplementary material composition is complex relatively. The ingredient material make the thymopentin solid preparation composition stable
and the efficacy could be developed. The high value for application could be obtained by improve the bioavailability thymopentin solid preparation.