The secondary metabolites and bioactivities of mangrove endophytic fungus Aspergillus sp. 5Y in Yangjiang

LI Haibin; LAN Xiong; LIU Ting; GUO Junxin; HUANG Huarong; ZHANG Kun

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The secondary metabolites and bioactivities of mangrove endophytic fungus Aspergillus sp. 5Y in Yangjiang

更新时间：2023-12-11

- The secondary metabolites and bioactivities of mangrove endophytic fungus Aspergillus sp. 5Y in Yangjiang
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 56, Issue 3, Pages: 100-104(2017)
- 作者机构：
  
  广东工业大学轻工化工学院,广东,广州,510006
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2017，
  
  Published Online：25 May 2017，
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LI Haibin, LAN Xiong, LIU Ting, et al. The secondary metabolites and bioactivities of mangrove endophytic fungus Aspergillus sp. 5Y in Yangjiang. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 56(3):100-104(2017)
DOI：

LI Haibin, LAN Xiong, LIU Ting, et al. The secondary metabolites and bioactivities of mangrove endophytic fungus Aspergillus sp. 5Y in Yangjiang. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 56(3):100-104(2017) DOI：

摘要

对阳江红树林内生真菌Aspergillus sp. 5Y的次级代谢产物进行研究。本文采用硅胶柱层析、LH-20凝胶柱层析、ODS-C

反相硅胶柱层析及HPLC等色谱技术，应用红外、紫外、质谱、核磁等现代波谱技术手段。通过对阳江红树林内生真菌Aspergillus sp.5Y进行次级代谢产物的研究，获得5个单体化合物，分别为6-epi-ophiobolin P(1)、strobilactone A(2)、penicisochroman E(3)、asperterpenol B(4)和(E，E')-6-(6′，7′-dihydroxy-2′，4′-octadienoyl)-strobilactone A(5)。在α-葡萄糖苷酶抑制实验中，化合物1，4对α-葡萄糖苷酶有显著的活性，IC

分别为(676.09±10.3) μmol/L和(9.57±0.2) μmol/L，为口服降糖药物的研发提供一定的理论数据。

Abstract

The secondary metabolites of mangrove endophytic fungus Aspergillus sp.5Y was studied in this work.The chemical constituents were isolated and purified through silical gel

Sephadex LH-20

ODS-C

columnchromatography and HPLC and identified through IR

mass anylysis and NMR specctroscopy. Five compounds were isolated from secondary metabolites of mangrove endophytic fungus Aspergillus sp.5Y and their structures were identified as 6-epi-ophiobolin P(1)

strobilactone A(2)

penicisochroman E(3)

asperterpenol B(4)

and (E

E')-6-(6′

7′-dihydroxy-2′

4′-octadienoyl)-strobilactone A(5).Compound 1

4 have a good inhibition on α-glucosidase

values of (600.13±10.3) μmol/L

(9.57±0.) μmol/L respectively

which provides a certain theoretical data for researching and developing oral hypoglycemic drugs

关键词

红树林内生真菌次级代谢产物

Keywords

mangroveendophytic fungussecondary metabolites

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