Amide metabolites of the mangrove endophytic fungus Phomopsis sp. ZZF08 from the South China Sea

TAO Yiwen; LING Huiping; ZHANG Jianye; SHE Zhigang; LIN Yongcheng

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Amide metabolites of the mangrove endophytic fungus Phomopsis sp. ZZF08 from the South China Sea

更新时间：2023-12-11

- Amide metabolites of the mangrove endophytic fungus Phomopsis sp. ZZF08 from the South China Sea
- Acta Scientiarum Naturalium Universitatis SunYatseni Vol. 56, Issue 5, Pages: 73-78(2017)
- 作者机构：
  
  1. 广州医科大学药学院,广东,广州,511436
  2. 
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2017，
  
  Published Online：25 September 2017，
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TAO Yiwen, LING Huiping, ZHANG Jianye, et al. Amide metabolites of the mangrove endophytic fungus Phomopsis sp. ZZF08 from the South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 56(5):73-78(2017)
DOI：

TAO Yiwen, LING Huiping, ZHANG Jianye, et al. Amide metabolites of the mangrove endophytic fungus Phomopsis sp. ZZF08 from the South China Sea. [J]. Acta Scientiarum Naturalium Universitatis SunYatseni 56(5):73-78(2017) DOI：

摘要

采用色谱技术对红树林内生真菌Phomopsis sp. ZZF08代谢产物进行分离纯化，MS、NMR、X-单晶衍射及与文献数据比对等方法确定其结构，MTT法考察其对体外人鼻咽癌细胞KB和KBv200的毒性作用。结果表明，由红树林内生真菌Phomopsis sp.ZZF08培养液中分离得到12个酰胺类化合物，经鉴定，分别为viridicatol (1)、cytochalasin H (2)、cytochalasin IV (3)、葡萄糖神经酰胺 (4)、△

4(5) (

E)-鞘氨醇-正十六碳酰胺 (5)、尿囊素 (6)、胸腺嘧啶 (7)、尿嘧啶 (8)、环(亮-甘)二肽 (9)、环(亮-丙)二肽 (10)、环(苯丙-甘)）二肽 (11)和环(苯丙-丙)二肽 (12)，其中，化合物1，2，3，4，5为首次从湛江红树林内生真菌Phomopsis sp. 中发现。体外细胞毒性实验表明化合物2，3对KB细胞和KBv200细胞有较强细胞毒性。

Abstract

The amide metabolites ofPhomopsis sp. ZZF08 from the South China Sea were isolated and purified by chromatography. Their structures were determined by MS

NMR

X-ray diffraction data and comparison with the literature data. Cytotoxicity in vitro was performed by tetrazolium (MTT) assay. Twelve amide compounds were isolated

which were viridicatol (1)

cytochalasin H (2)

cytochalasin IV (3)

glucosylceramide (4)

ceramide (5)

allantoin (6)

thymine (7)

pyridine (8)

cyclo-(Leu-Gly) (9)

cyclo- (Leu Ala) (10)

cyclo- (Phe Gly) (11)

and cyclo- (Phe-Ala) (12). Compounds 1，2，3，4 and 5 were isolated firstly from Phomopsis sp. collected from the mangrove bark of the Zhanjiang. In our cytotoxicity assays

compounds 2 and 3 exhibited strong cytotoxicity toward KB cells and KBv200 cells.

关键词

红树林内生真菌拟茎点霉菌酰胺类次级代谢产物

Keywords

mangroveendophytic fungusPhomopsis sp.amide metabolites

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Related Institution

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